ArticleScientific reports2019
Elevated CO
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Comparing effects of breathing exercises alone and combined with breathing-stretching exercises on respiratory indices, disease severity and exercise capacity in COPD.Scientific reports · 2025Trial
- Hypercapnia enhances airway smooth muscle contractility via STIM1-dependent Ca2+ signaling.JCI insight · 2026Article
- Stable bioreactor control reveals acidic pH-driven metabolic reprogramming and mitochondrial dysfunction in human lymphoblastoid cells.Communications biology · 2026Article
- Long-term DNA methylation changes induced by age and elevated COSkeletal muscle · 2025Article
- Sensing molecular carbon dioxide: a translational focus for respiratory disease.Physiological reviews · 2025Review
- Gene Expression Profiling of Pancreatic Ductal Adenocarcinoma Cells in Hypercapnia Identifies SIAH3 as a Novel Prognostic Biomarker.International journal of molecular sciences · 2025Article
- Effect of extended egg quiescence and elevation in carbon dioxide on life history traits of Aedes aegypti.Scientific reports · 2025Article
- Rapamycin improves satellite cells' autophagy and muscle regeneration during hypercapnia.JCI insight · 2025Article
- Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia.International journal of molecular sciences · 2024Article
- Mild and moderate chronic hypercapnia elicit distinct transcriptomic responses of immune function in cardiorespiratory nuclei.Physiological genomics · 2023Article
- Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells.JCI insight · 2023Article
- Site-Specific Detection and Characterization of Ubiquitin Carbamylation.Biochemistry · 2022Article
- Editorial: Elevated Carbon Dioxide Sensing and Physiologic Effects.Frontiers in physiology · 2022Article
- Elevated COInterface focus · 2021Review
- Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage.Interface focus · 2021Article
- Carbon dioxide-dependent signal transduction in mammalian systems.Interface focus · 2021Review
- Hypercapnia in the critically ill: insights from the bench to the bedside.Interface focus · 2021Review
- Mechanisms of Hypercapnia-Induced Endoplasmic Reticulum Dysfunction.Frontiers in physiology · 2021Review
- Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan ReceptorsFrontiers in immunology · 2021Article
- Hypercapnia: An Aggravating Factor in Asthma.Journal of clinical medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 5 countries.
Masahiko ShigemuraDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.ORCID http://orcid.org/0000-0001-7767-6584
Emilia LecuonaDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Martín AnguloPathophysiology Department, School of Medicine, Universidad de la República, Montevideo, Uruguay.
Laura A DadaDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Melanie B EdwardsDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Lynn C WelchDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.ORCID http://orcid.org/0000-0003-1666-3696
S Marina Casalino-MatsudaDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.ORCID http://orcid.org/0000-0002-7566-4560
Peter H S SpornDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.ORCID http://orcid.org/0000-0002-1006-9437
István VadászDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, German Center for Lung Research, and The Cardio-Pulmonary Institute, Giessen, Germany.
Iiro Taneli HeleniusDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Gustavo A NaderDepartment of Kinesiology and Huck Institutes of the Life Sciences, The Pennsylvania State University, State College, PA, United States of America.
Yosef GruenbaumDepartment of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel.
Kfir SharabiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States of America.
Eoin CumminsSchool of Medicine, Systems Biology Ireland and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, 4, Ireland.ORCID http://orcid.org/0000-0002-9346-8299
Cormac TaylorSchool of Medicine, Systems Biology Ireland and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, 4, Ireland.
Ankit BharatDivision of Thoracic Surgery, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Cara J GottardiDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.ORCID http://orcid.org/0000-0003-0912-7617
Greg J BeitelDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, United States of America.ORCID http://orcid.org/0000-0003-4413-6324
Naftali KaminskiDepartment of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States of America.
G R Scott BudingerDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.
Sergejs BerdnikovsDivision of Allergy and Immunology, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Jacob I SznajderDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America. j-sznajder@northwestern.edu.ORCID http://orcid.org/0000-0002-2089-4764
Northwestern University · USUniversity College Dublin · IEBoston University · USGerman Center for Lung Research · DEHebrew University of Jerusalem · ILPennsylvania State University · USUniversidad de la República de Uruguay · UYYale University · US
Funding
Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MRole of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgeryR01HL147575 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.5MPathogenesis of lung injury mediated by lung-restricted antibodiesR01HL147290 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.2MDonor nonclassical monocytes mediate primary graft dysfunction and remote organ injury following lung transplant surgeryR01HL145478 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$4.8MRole of hypercapnia on the lung airwaysR01HL147070 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2019 to 2022
$1.9MRole for Wnt/beta-catenin signaling in alveolar repair and fibrosisR01HL094643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOTTARDI, CARA J · 2011 to 2014
$1.5MGenes Mediating Innate Immune Suppression by Hypercapnia in Mammals and FliesR01HL107629 · NHLBI · NORTHWESTERN UNIVERSITY · PI BEITEL, GREG J, SPORN, PETER H · 2012 to 2015
$1.5MHypercapnia and Suppression of Anti-viral Host DefenseR01HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2017 to 2019
$1.2MHypercapnia and Suppression of Anti-viral Host DefenseR56HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2016 to 2016
$391kNHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL094643NHLBI NIH HHS R01 HL107629NHLBI NIH HHS R01 HL131745NHLBI NIH HHS R01 HL145478NHLBI NIH HHS R01 HL147070NHLBI NIH HHS R01 HL147290NHLBI NIH HHS R01 HL147575NHLBI NIH HHS R56 HL131745NIA NIH HHS P01 AG049665
Abstract
Carbon dioxide (CO
Indexed as
AnimalsBronchiCaenorhabditis elegansCarbon DioxideCell LineDrosophila melanogasterGene Expression ProfilingHumansHypercapniaMaleMiceMice, Inbred C57BLReal-Time Polymerase Chain ReactionTissue Array AnalysisWnt Signaling PathwayCarbon Dioxide
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.