Trial reportScientific reports2019
Cortical neurodynamics changes mediate the efficacy of a personalized neuromodulation against multiple sclerosis fatigue.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Biomarker use in predicting transcranial direct-current stimulation (tDCS) response: a systematic scoping review.Frontiers in psychiatry · 2026Pooled it
- Examining electroencephalogram signatures of people with multiple sclerosis using a nonlinear dynamics approach: a systematic review and bibliographic analysis.Frontiers in computational neuroscience · 2023Pooled it
- Effects of Transcranial Direct Current Stimulation on Cognition, Mood, Pain, and Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Combined cognitive rehabilitation and neurofeedback therapy: effects on executive function and cognitive flexibility in people with multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Trial
- Fractal dynamics of the healthy human brain: A subcortical-to-cortical gradient of temporal complexity.iScience · 2026Article
- Fatigue relief: the contribution of non-invasive neuromodulation (FAREviaNM).Frontiers in neuroscience · 2026Article
- Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study.PloS one · 2025Article
- Neural correlates of fatigue after traumatic brain injury.Brain communications · 2025Article
- Review
- Editorial: Methods and application in fractal analysis of neuroimaging data.Frontiers in human neuroscience · 2024Article
- Characterization of antiseizure medications effects on the EEG neurodynamic by fractal dimension.Frontiers in neuroscience · 2024Article
- Musician's dystonia: an opinion on novel treatment strategies.Frontiers in neuroscience · 2024Article
- Clinical Sensitivity of Fractal Neurodynamics.Advances in neurobiology · 2024Article
- Personalized strategies of neurostimulation: from static biomarkers to dynamic closed-loop assessment of neural function.Frontiers in neuroscience · 2024Review
- Fractal Time Series: Background, Estimation Methods, and Performances.Advances in neurobiology · 2024Review
- Electroencephalography-Derived Functional Connectivity in Sensorimotor Networks in Post Stroke Fatigue.Brain topography · 2023Article
- Effects on Corticospinal Tract Homology of Faremus Personalized Neuromodulation Relieving Fatigue in Multiple Sclerosis: A Proof-of-Concept Study.Brain sciences · 2023Article
- Functional balance at rest of hemispheric homologs assessed via normalized compression distance.Frontiers in neuroscience · 2023Article
- Editorial: Combined EEG in research and diagnostics: Novel perspectives and improvements.Frontiers in neuroscience · 2023Article
- Functional Source Separation-Identified Epileptic Network: Analysis Pipeline.Brain sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The people with multiple sclerosis (MS) often report that fatigue restricts their life. Nowadays, pharmacological treatments are poorly effective accompanied by relevant side effects. A 5-day transcranial direct current stimulation (tDCS) targeting the somatosensory representation of the whole body (S1) delivered through an electrode personalized based on the brain MRI was efficacious against MS fatigue (FaReMuS treatment). This proof of principle study tested whether possible changes of the functional organization of the primary sensorimotor network induced by FaReMuS partly explained the effected fatigue amelioration. We measured the brain activity at rest through electroencephalography equipped with a Functional Source Separation algorithm and we assessed the neurodynamics state of the primary somatosensory (S1) and motor (M1) cortices via the Fractal Dimension and their functional connectivity via the Mutual Information. The dynamics of the neuronal electric activity, more distorted in S1 than M1 before treatment, as well as the network connectivity, altered maximally between left and right M1 homologs, reverted to normal after FaReMuS. The intervention-related changes explained 48% of variance of fatigue reduction in the regression model. A personalized neuromodulation tuned in on specific anatomo-functional features of the impaired regions can be effective against fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.