ArticleScientific reports2019
Agastache honey has superior antifungal activity in comparison with important commercial honeys.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Medicinal Honeys from Oceania: An Updated Review on Their Bioactive Constituents and Health Applications.Biotech (Basel (Switzerland)) · 2026Review
- Natural clearance time and effect of manuka honey body wash and oral probiotics on colonization ofFrontiers in public health · 2026Article
- Brazilian Organic Honeydew Reduces In Vitro and In Vivo Periodontal Disease-Related Subgingival Biofilm.Foods (Basel, Switzerland) · 2025Article
- Honey microbiota, methods for determining the microbiological composition and the antimicrobial effect of honey - A review.Food chemistry: X · 2024Review
- The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review.Journal of xenobiotics · 2024Review
- Article
- Natural Substances as Valuable Alternative for Improving Conventional Antifungal Chemotherapy: Lights and Shadows.Journal of fungi (Basel, Switzerland) · 2024Review
- Review
- The Antifungal and Anti-Pneumocystis Activities of the Novel Compound A3IS (Mycosinate).Antimicrobial agents and chemotherapy · 2022Article
- Honey: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applications.Pharmaceutics · 2022Review
- SDS-PAGE Protein and HPTLC Polyphenols Profiling as a Promising Tool for Authentication of Goldenrod Honey.Foods (Basel, Switzerland) · 2022Article
- Diversity of Monofloral Honey Based on the Antimicrobial and Antioxidant Potential.Antibiotics (Basel, Switzerland) · 2022Article
- Characterization of Ikaria Heather Honey by Untargeted Ultrahigh-Performance Liquid Chromatography-High Resolution Mass Spectrometry Metabolomics and Melissopalynological Analysis.Frontiers in chemistry · 2022Article
- Promising Antimicrobial Properties of Bioactive Compounds from Different Honeybee Products.Molecules (Basel, Switzerland) · 2021Review
- Biological Properties of Bee Bread Collected from Apiaries Located across Greece.Antibiotics (Basel, Switzerland) · 2021Article
- Chemical Analyses and Antimicrobial Activity of Nine Kinds of Unifloral Chinese Honeys Compared to Manuka Honey (12+ and 20+).Molecules (Basel, Switzerland) · 2021Article
- Inhibition of Dermatophyte Fungi by Australian Jarrah Honey.Pathogens (Basel, Switzerland) · 2021Article
- Antifungal Activity of a Medical-Grade Honey Formulation againstJournal of fungi (Basel, Switzerland) · 2021Article
- Antimicrobial Activity of Bee-Collected Pollen and Beebread: State of the Art and Future Perspectives.Antibiotics (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an urgent need for new effective antifungal agents suitable for the treatment of superficial skin infections, since acquired resistance of fungi to currently available agents is increasing. The antifungal activity of mono-floral Agastache honey and commercially available honeys were tested against dermatophytes (T. mentagrophytes and T. rubrum) and C. albicans (ATCC 10231 and a clinical isolate) by agar well diffusion and micro-dilution (AWD and MD). In AWD and MD assays, Agastache honey was effective at 40% concentration against dermatophytes (zone diameter, 19.5-20 mm) and C. albicans with the same MIC and MFC values indicating fungicidal activity. Tea tree honey was effective at 80% concentration (zone diameter, 14 mm) against dermatophytes and at 40% concentration against T. mentagrophytes and C. albicans. Manuka was effective at 80% concentration only against T. mentagrophytes (zone diameter, 12 mm) and at 40% against T. rubrum and C. albicans with fungistatic activity. Similar to the AWD results, Jelly bush, Super Manuka, and Jarrah showed no activity against dermatophytes but showed some activity against C. albicans. Headspace volatiles of six honeys were isolated by SPME and identified by GC-MS. The characteristic chemical markers for each honey were as follows: Agastache- Phenol, 2,4-bis(1,1-dimethylethyl) and Estragole; Manuka and Tea-tree- Acetanisole and Methyl 3,5-dimethoxybenzoate; Jelly bush- Linalool and Nonanal; Super Manuka- Methyl 3,5-dimethoxybenzoate and Nonanal; Jarrah- Isophorone and Nonanoic acid. Overall, analysis of the bioactive compound content and antifungal activity of Agastache honey indicated possible use as an antifungal agent for management of superficial fungal infections.
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