ArticleScientific reports2019
Apolipoprotein E deficient rats generated via zinc-finger nucleases exhibit pronounced in-stent restenosis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Surgical Rodent Models for the Study of Peripheral Arterial Disease.Biomedicines · 2026Review
- Evaluation of expansion and crossing profile characteristics of micro laser powder bed fusion-manufactured coronary stents in a rat model.Scientific reports · 2025Article
- Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat.Experimental animals · 2023Article
- Intraprocedural endothelial cell seeding of arterial stents via biotin/avidin targeting mitigates in-stent restenosis.Scientific reports · 2022Article
- Animal Models of Neointimal Hyperplasia and Restenosis: Species-Specific Differences and Implications for Translational Research.JACC. Basic to translational science · 2021Review
- Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy-An Animal and In-Human Comparative Study.International journal of molecular sciences · 2021Article
- Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models.International journal of molecular sciences · 2021Article
- Impacts ofDrug design, development and therapy · 2020Article
- Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy.Frontiers in cardiovascular medicine · 2020Review
- Heart function assessment during aging in apolipoprotein E knock-out mice.Discoveries (Craiova, Romania)Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long-term success of coronary stent implantation is limited by in-stent restenosis (ISR). In spite of a broad variety of animal models available, an ideal high-throughput model of ISR has been lacking. Apolipoprotein E (apoE) deficient rats enable the evaluation of human-sized coronary stents while at the same time providing an atherogenic phenotype. Whereas apoE deficient rats have been proposed as animal model of atherosclerosis, to date it is unknown whether they also develop pronounced ISR. We sought to assess ISR after abdominal aorta stent implantation in apoE deficient rats. A total of 42 rats (16 wildtype, 13 homozygous apoE
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