ArticleScientific reports2019
Honey can inhibit and eliminate biofilms produced by Pseudomonas aeruginosa.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
53 citing papers in PubMed, 94 citations in OpenAlex.
- Plant-Derived Compounds as Antibiotic Adjuvants Against Drug-Resistant ESKAPE Pathogens: Mechanisms of Action, Synergistic Strategies, and Translational Challenges.Antibiotics (Basel, Switzerland) · 2026Review
- Combination of Manuka Honey and Chitosan-Based Biomaterial for the Treatment of Dehisced Wound: Case Report.Life (Basel, Switzerland) · 2026Article
- Clinical and Postoperative Applications of Manuka Honey in Wound Healing: An Evidence-Based Review.International wound journal · 2026Review
- Real-World Experience in the Treatment of Biofilm-Associated Wounds Using Medical-Grade Honey: A Retrospective Case Series.Antibiotics (Basel, Switzerland) · 2026Article
- Manuka honey as a natural remedy for diabetic foot ulcers: efficacy compared with silver-based dressing.Frontiers in pharmacology · 2026Article
- In Vitro Antimicrobial Activity of Five Turkish Honey Types Against Otitis Externa Pathogens: A Comparative Study.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Biofilms and Chronic Wounds: Pathogenesis and Treatment Options.Journal of clinical medicine · 2025Review
- Testing Sonication and Different Transport Media to Enhance Microbial Detection in Hard-to-Heal Venous Leg Ulcers.International wound journal · 2025Observational
- The Elimination Effect of Medical-Grade Honey onJournal of clinical medicine research · 2025Article
- Formulation and evaluation of therapeutic antimicrobial citrus and Manuka honey creams with aloe vera, mint essential oil, and Indian costus.Scientific reports · 2025Article
- Honey as a Natural Antimicrobial.Antibiotics (Basel, Switzerland) · 2025Review
- Exploring the antibacterial and anti-biofilm activity of two Iranian medical-grade kinds of honey on multidrug-resistant Pseudomonas aeruginosa.BMC complementary medicine and therapies · 2025Article
- Honey microbiota, methods for determining the microbiological composition and the antimicrobial effect of honey - A review.Food chemistry: X · 2024Review
- Bee-Inspired Healing: Apitherapy in Veterinary Medicine for Maintenance and Improvement Animal Health and Well-Being.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Efficacy of sucrose and povidone-iodine mixtures in peritoneal dialysis catheter exit-site care.BMC nephrology · 2024Observational
- Lipid Nanocarriers-Enabled Delivery of Antibiotics and Antimicrobial Adjuvants to Overcome Bacterial Biofilms.Pharmaceutics · 2024Review
- Studies on bioactivities of Manuka and regional varieties of honey for their potential use as natural antibiotic agents for infection control related to wound healing and in pharmaceutical formulations.AIMS microbiology · 2024Review
- PCL-gelatin honey scaffolds promoteFrontiers in microbiology · 2024Article
- The impact of wound pH on the antibacterial properties of Medical Grade Honey when applied to bacterial isolates present in common foot and ankle wounds. An in vitro study.Journal of foot and ankle research · 2023Article
- The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study.Antibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wound treatment is becoming increasingly difficult and costly, further exacerbated when wounds become infected. Bacterial biofilms cause most chronic wound infections and are notoriously resistant to antibiotic treatments. The need for new approaches to combat polymicrobial biofilms in chronic wounds combined with the growing antimicrobial resistance crisis means that honey is being revisited as a treatment option due to its broad-spectrum antimicrobial activity and low propensity for bacterial resistance. We assessed four well-characterised New Zealand honeys, quantified for their key antibacterial components, methylglyoxal, hydrogen peroxide and sugar, for their capacity to prevent and eradicate biofilms produced by the common wound pathogen Pseudomonas aeruginosa. We demonstrate that: (1) honey used at substantially lower concentrations compared to those found in honey-based wound dressings inhibited P. aeruginosa biofilm formation and significantly reduced established biofilms; (2) the anti-biofilm effect of honey was largely driven by its sugar component; (3) cells recovered from biofilms treated with sub-inhibitory honey concentrations had slightly increased tolerance to honey; and (4) honey used at clinically obtainable concentrations completely eradicated established P. aeruginosa biofilms. These results, together with their broad antimicrobial spectrum, demonstrate that manuka honey-based wound dressings are a promising treatment for infected chronic wounds, including those with P. aeruginosa biofilms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.