Evidence map›Paper›PMID 31796755›Full record

ArticleScientific reports2019

Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management.

Paula Parreira, Claudia Monteiro, Vanessa Graça, Joana Gomes, Sílvia Maia, Paula Gomes, Inês C Gonçalves, M Cristina L Martins

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  7. Biofilm ofAntibiotics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Paula Parreirai3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Claudia Monteiroi3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Vanessa GraçaINEB, Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal.ORCID http://orcid.org/0000-0003-0131-7651
Joana Gomesi3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Sílvia MaiaLAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.
Paula GomesLAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.
Inês C Gonçalvesi3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
M Cristina L Martinsi3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. cmartins@ineb.up.pt.ORCID http://orcid.org/0000-0002-6574-4794
Universidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As we approach the end of the antibiotic era, newer therapeutic options, such as antimicrobial peptides (AMPs), are in urgent demand. AMP surface grafting onto biomaterials has been described as a good strategy to overcome problems associated with their in vivo stability. Helicobacter pylori is among the bacteria that pose greatest threat to human health, being MSI-78A one of the few bactericidal AMPs against this bacterium. Here, we report that MSI-78A grafted onto model surfaces (Self-Assembled Monolayers -SAMs), in a concentration of 30.3 ± 1.2 ng/cm

Indexed as

Antimicrobial Cationic PeptidesBiocompatible MaterialsBioengineeringDrug Delivery SystemsHelicobacter InfectionsHelicobacter pyloriHumansMicrobial Sensitivity TestsNanoparticlesProof of Concept StudyQuartz Crystal Microbalance TechniquesStaphylococcus aureusStomach DiseasesAntimicrobial Cationic PeptidesBiocompatible Materialspexiganan

Identifiers

PMID31796755
PMCPMC6890677
OpenAlexW2993271634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.