ArticleNature communications2019
Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 95 citations in OpenAlex.
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- Controlled Reassociation of Multistranded, Polycrossover DNA Molecules into Double Helices.Nano letters · 2025Article
- Kinetics and Activation Strategies in Toehold-Mediated and Toehold-Free DNA Strand Displacement.Biosensors · 2025Review
- Article
- Rationally Designed DNA-Based Scaffolds and Switching Probes for Protein Sensing.Advances in biochemical engineering/biotechnology · 2024Review
- Bispecific Antibody Detection Using Antigen-Conjugated Synthetic Nucleic Acid Strands.ACS sensors · 2023Article
- Engineering DNA-based cytoskeletons for synthetic cells.Interface focus · 2023Review
- Metal-mediated DNA strand displacement and molecular device operations based on base-pair switching of 5-hydroxyuracil nucleobases.Nature communications · 2023Article
- Thermofluorimetric Analysis (TFA) using Probes with Flexible Spacers: Application to Direct Antibody Sensing and to Antibody-Oligonucleotide (AbO) Conjugate Valency Monitoring.Analytical chemistry · 2023Article
- Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and Characterization.ACS sensors · 2023Review
- Encoding, Decoding, and Rendering Information in DNA Nanoswitch Libraries.ACS synthetic biology · 2023Article
- Design, Mechanical Properties, and Dynamics of Synthetic DNA Filaments.Bioconjugate chemistry · 2023Review
- Active Self-Assembly of Ladder-Shaped DNA Carrier for Drug Delivery.Molecules (Basel, Switzerland) · 2023Article
- Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle.Journal of the American Chemical Society · 2022Article
- Dissipative DNA nanotechnology.Nature chemistry · 2022Review
- Programmable Cell-Free Transcriptional Switches for Antibody Detection.Journal of the American Chemical Society · 2022Article
- Chemiluminescent screening of specific hybridoma cells via a proximity-rolling circle activated enzymatic switch.Communications biology · 2022Article
- Antigen-Triggered Logic-Gating of DNA Nanodevices.Journal of the American Chemical Society · 2021Article
- Determinants of Ligand-Functionalized DNA Nanostructure-Cell Interactions.Journal of the American Chemical Society · 2021Article
- Programmable, Multiplexed DNA Circuits Supporting Clinically Relevant, Electrochemical Antibody Detection.ACS sensors · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report a rational strategy to orthogonally control assembly and disassembly of DNA-based nanostructures using specific IgG antibodies as molecular inputs. We first demonstrate that the binding of a specific antibody to a pair of antigen-conjugated split DNA input-strands induces their co-localization and reconstitution into a functional unit that is able to initiate a toehold strand displacement reaction. The effect is rapid and specific and can be extended to different antibodies with the expedient of changing the recognition elements attached to the two split DNA input-strands. Such an antibody-regulated DNA-based circuit has then been employed to control the assembly and disassembly of DNA tubular structures using specific antibodies as inputs. For example, we demonstrate that we can induce self-assembly and disassembly of two distinct DNA tubular structures by using DNA circuits controlled by two different IgG antibodies (anti-Dig and anti-DNP antibodies) in the same solution in an orthogonal way.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.