Evidence map›Paper›PMID 31796631›Full record

ArticleScience signaling2019

Biased M

Sean P Moran, Zixiu Xiang, Catherine A Doyle, James Maksymetz, Xiaohui Lv, Sehr Faltin, Nicole M Fisher, Colleen M Niswender, Jerri M Rook, Craig W Lindsley and 1 more

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Leveraging bias to your advantage.Nature chemical biology · 2020
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sean P MoranVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-7672-242X
Zixiu XiangDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-1678-209X
Catherine A DoyleVanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-5415-2371
James MaksymetzDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-0486-1153
Xiaohui LvVanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Sehr FaltinVanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Nicole M FisherDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-6740-9618
Colleen M NiswenderDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-6009-8212
Jerri M RookVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-0168-1445
P Jeffrey ConnVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA. jeff.conn@vanderbilt.edu.ORCID 0000-0003-2363-0323
Vanderbilt University · US

Funding

REGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9M
Vanderbilt NCDDDG for Discovery of Novel Treatments for SchizophreniaU01MH087965 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2010 to 2014
$9.3M
Muscarinic receptor activators as novel antipsychotic agentsR01MH073676 · NIMH · VANDERBILT UNIVERSITY · PI Jerri Michelle Rook · 2006 to 2026
$9.3M
Training in Fundamental NeuroscienceT32MH064913 · NIMH · VANDERBILT UNIVERSITY · PI IHRIE, REBECCA A, WINDER, DANNY G. · 2001 to 2022
$7.6M
Selective M1 mAChR allosteric modulators for the treatment of schizophreniaR01MH082867 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2008 to 2017
$3.7M
mGlu Allosteric Modulation in Neurodegenerative DiseasesR01AG051626 · NIA · VANDERBILT UNIVERSITY · PI ROOK, JERRI MICHELLE · 2016 to 2020
$2.0M
Role of Phospholipase D in M1 Allosteric Modulation of Synaptic Plasticity: Implications for the Treatment of SchizophreniaF31MH114368 · NIMH · VANDERBILT UNIVERSITY · PI MORAN, SEAN PATRICK · 2017 to 2019
$71k
NIA NIH HHS R01 AG051626NIMH NIH HHS F31 MH114368NIMH NIH HHS R01 MH062646NIMH NIH HHS R01 MH073676NIMH NIH HHS R01 MH082867NIMH NIH HHS T32 MH064913NIMH NIH HHS U01 MH087965
6 · The paper itself

Abstract

Highly selective, positive allosteric modulators (PAMs) of the M

Indexed as

Neuronal PlasticityAllosteric SiteAnimalsCalciumCerebral CortexCHO CellsCognitionCricetinaeCricetulusElectrophysiologyFemaleHumansLong-Term Synaptic DepressionMaleMiceMice, Inbred C57BLCalciumPhospholipase Dphospholipase D1Receptor, Muscarinic M1Type C Phospholipases

Identifiers

PMID31796631
PMCPMC6936752
OpenAlexW2991785321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.