ArticleScience signaling2019
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
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Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
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Who cites it
44 citing papers in PubMed, 56 citations in OpenAlex.
- Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.Cell reports. Medicine · 2023Trial
- Article
- Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study.Clinical epigenetics · 2026Article
- A gene therapy strategy for Deoxyhypusine Synthase (DHPS) syndrome.Research square · 2026Article
- Translating the blueprint of cell fate: eIF5A-mediated translation regulates cellular identity in the pancreas.Molecular metabolism · 2026Article
- Using animal models to decipher the role of polyamines in the pancreas and β Cell.Amino acids · 2026Review
- Article
- Alterations in Gut Microbial Co-Abundance Networks in Metabolic Syndrome: A Population-Based Cross-Sectional Study.Microorganisms · 2025Article
- Deletion of neuronal Idol ameliorates Alzheimer's disease-related pathologies via APOE receptors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Protective role of epithelial deoxyhypusine synthase in colorectal carcinogenesis caused by deletion of the adenomatous polyposis coli gene.Cancer letters · 2025Article
- Cyst fluid proteins stratify malignant risk of intraductal papillary mucinous neoplasm of the pancreas.Cancer letters · 2025Article
- Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function.The Journal of biological chemistry · 2025Article
- Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression.Nature cell biology · 2024Article
- Deletion of miR-33, a regulator of the ABCA1-APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Many Faces of Hypusinated eIF5A: Cell Context-Specific Effects of the Hypusine Circuit and Implications for Human Health.International journal of molecular sciences · 2024Review
- A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates β-Cell Identity and Function.Diabetes · 2024Article
- Discordant Effects of Polyamine Depletion by DENSpm and DFMO on β-cell Cytokine Stress and Diabetes Outcomes in Mice.Endocrinology · 2024Article
- The impact of abstinence from chronic alcohol consumption on the mouse striatal proteome: sex and subregion-specific differences.Frontiers in pharmacology · 2024Article
- Ghrelin deletion and conditional ghrelin cell ablation increase pancreatic islet size in mice.The Journal of clinical investigation · 2023Article
- Good cop, bad cop: Polyamines play both sides in host immunity and viral replication.Seminars in cell & developmental biology · 2023Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Esther M LevasseurCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-1337-8032
Kentaro YamadaCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Annie R PiñerosCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0135-7549
Wenting WuCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0982-771X
Farooq SyedCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0284-0631
Kara S OrrCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-1321-8581
Emily Anderson-BaucumIndiana Biosciences Research Institute, Indianapolis, IN 46202, USA.ORCID 0000-0003-3132-7295
Teresa L MastracciDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-1956-1951
Bernhard MaierDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8174-0873
Amber L MosleyDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-5822-2894
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2699-626X
Ernesto Bernal-MizrachiDepartment of Medicine, University of Miami, Miami, FL 33146, USA.ORCID 0000-0001-9997-3301
Laura C AlonsoDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Donald ScottDiabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-1414-9223
Adolfo Garcia-OcañaDiabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-6883-6176
Sarah A TerseyCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0667-2361
Raghavendra G MirmiraCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA. mirmira@uchicago.edu.ORCID 0000-0002-5013-6075
Indiana University School of MedicineChild Health and Development Institute · USIndiana Biosciences Research Institute · USUniversity of Massachusetts Chan Medical School · USUniversity of Miami · US
Funding
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9MIntegrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8MTranslation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MTranscriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5MValidation of small molecule 12-lipoxygenase inhibitors in metabolic diseaseR01DK105588 · NIDDK · UNIVERSITY OF CHICAGO · PI KULKARNI, ROHIT N., MIRMIRA, RAGHAVENDRA G · 2015 to 2024
$5.5MDYRK Inhibitors for Human Beta Cell ExpansionR01DK105015 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVITA, ROBERT J, GARCIA-OCANA, ADOLFO · 2016 to 2024
$4.9MAKT/mTOR Signaling and Regulation of Cell Cycle in beta CellsR01DK073716 · NIDDK · WASHINGTON UNIVERSITY · PI BERNAL-MIZRACHI, ERNESTO · 2006 to 2022
$4.6MDextran Sulfate, Beta Cell Preservation and Immune Regulation in Type 1 DiabetesR01DK113079 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-OCANA, ADOLFO, HOMANN, DIRK · 2017 to 2020
$1.7MProtein Kinase C (PKC) Zeta and the Pancreatic Beta CellR01DK077096 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GARCIA-OCANA, ADOLFO · 2008 to 2012
$1.6MBLRD VA I01 BX002728NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK060581NIDDK NIH HHS R01 DK073716NIDDK NIH HHS R01 DK077096NIDDK NIH HHS R01 DK105015NIDDK NIH HHS R01 DK105588NIDDK NIH HHS R01 DK113079NIDDK NIH HHS U24 DK098085
Abstract
Deoxyhypusine synthase (DHPS) uses the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly defined mechanisms. Because germline deletion of
Indexed as
AgedAllelesAnimalsCell ProliferationCrosses, GeneticCyclin D2Diabetes Mellitus, ExperimentalDiet, High-FatEukaryotic Translation Initiation Factor 5AFemaleGene DeletionGlucoseHomeostasisHumansInsulin-Secreting CellsLysineCCND2 protein, humanCcnd2 protein, mouseCyclin D2Eukaryotic Translation Initiation Factor 5AGlucosehypusineLysineOrnithine DecarboxylasePeptide Initiation FactorsPolyaminesProtein Kinase CProtein Kinase C zetaProto-Oncogene Proteins c-mycRNA-Binding ProteinsRNA, Messenger
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.