Evidence map›Paper›PMID 31796629›Full record

ArticleThe Journal of biological chemistry2020

Membrane fluidity adjusts the insertion of the transacylase PlsX to regulate phospholipid biosynthesis in Gram-positive bacteria.

Diego E Sastre, Luis G M Basso, Beatriz Trastoy, Javier O Cifuente, Xabier Contreras, Frederico Gueiros-Filho, Diego de Mendoza, Marcos V A S Navarro, Marcelo E Guerin

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Fatty acid synthesis and utilization in gram-positive bacteria: insights fromMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  2. Article
  3. Growth ofmSphere · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. A FAS solution to a DEAD case.PLoS genetics · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Diego E SastreGrupo de Biofísica Molecular "Sergio Mascarenhas," Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, Brasil. Electronic address: diegosastre82@gmail.com.
Luis G M BassoDepartamento de Física, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brasil.
Beatriz TrastoyStructural Biology Unit, CIC bioGUNE Technological Park of Bizkaia, Derio, Vizcaya, Spain.
Javier O CifuenteStructural Biology Unit, CIC bioGUNE Technological Park of Bizkaia, Derio, Vizcaya, Spain.
Xabier ContrerasIKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain; Instituto Biofisika, Consejo Superior de Investigaciones Científicas, Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC,UPV/EHU), Barrio Sarriena s/n, Leioa, 48940 Bizkaia, Spain; Departamento de Bioquímica, Universidad del País Vasco, Leioa, 48940 Bizkaia, Spain.
Frederico Gueiros-FilhoDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
Diego de MendozaInstituto de Biología Molecular y Celular de Rosario (IBR), Rosario, Santa Fe, Argentina.
Marcos V A S NavarroGrupo de Biofísica Molecular "Sergio Mascarenhas," Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, Brasil.
Marcelo E GuerinStructural Biology Unit, CIC bioGUNE Technological Park of Bizkaia, Derio, Vizcaya, Spain; IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain. Electronic address: mrcguerin@cicbiogune.es.
Universidade de São Paulo · BRCIC bioGUNE · ESIkerbasque · ESInstituto de Biología Molecular y Celular de Rosario · ARUniversidade de Ribeirão Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PlsX plays a central role in the coordination of fatty acid and phospholipid biosynthesis in Gram-positive bacteria. PlsX is a peripheral membrane acyltransferase that catalyzes the conversion of acyl-ACP to acyl-phosphate, which is in turn utilized by the polytopic membrane acyltransferase PlsY on the pathway of bacterial phospholipid biosynthesis. We have recently studied the interaction between PlsX and membrane phospholipids

Indexed as

Bacillus subtilisBacterial ProteinsEnterococcus faecalisEscherichia coliGram-Positive BacteriaMembrane FluidityPhosphatesPhospholipidsBacterial ProteinsPhosphatesPhospholipidsplsX protein, bacteriaenzyme catalysisenzyme mechanismenzyme mutationenzyme structuremembrane bindingmembrane fluiditymembrane insertionphospholipid biosynthesisphospholipid metabolismprotein-lipid interaction

Identifiers

PMID31796629
PMCPMC7029129
OpenAlexW2993367563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.