Evidence map›Paper›PMID 31796596›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells.

M Valente, Y Dölen, E van Dinther, L Vimeux, M Fallet, V Feuillet, C G Figdor

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. CD1d-Restricted NKT Cells Promote Central Memory CD8International journal of molecular sciences · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Eosinophils promote CD8Signal transduction and targeted therapy · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. The role of natural killer T cells in liver transplantation.Frontiers in cell and developmental biology · 2023
    Review
  11. CD8Frontiers in immunology · 2022
    Review
  12. Allogeneic CAR Invariant Natural Killer T Cells Exert Potent Antitumor Effects through Host CD8 T-Cell Cross-Priming.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

M ValenteDepartment of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands; valente@ciml.univ-mrs.fr carl.figdor@radboudumc.nl.
Y DölenDepartment of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-8211-9811
E van DintherDepartment of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands.
L VimeuxUniversité de Paris, Institut Cochin, INSERM, U1016, CNRS, UMR8104, F-75014 Paris, France.
M FalletCentre d'Immunologie de Marseille-Luminy, Aix Marseille University, CNRS, INSERM, 13007 Marseille, France.
V FeuilletUniversité de Paris, Institut Cochin, INSERM, U1016, CNRS, UMR8104, F-75014 Paris, France.
C G FigdorDepartment of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands; valente@ciml.univ-mrs.fr carl.figdor@radboudumc.nl.
Centre National de la Recherche Scientifique · FRRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mounting an effective immune response relies critically on the coordinated interactions between adaptive and innate compartments. How and where immune cells from these different compartments interact is still poorly understood. Here, we demonstrate that the cross-talk between invariant natural killer T cells (iNKT) and CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationChemokine CCL17Chemokine CXCL9Dendritic CellsHomeodomain ProteinsImmunologic MemoryInterleukin-4Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNatural Killer T-CellsReceptor Cross-TalkReceptors, CCR4Ccl17 protein, mouseCcr4 protein, mouseChemokine CCL17Chemokine CXCL9Cxcl9 protein, mouseCxcr3 protein, mouseHomeodomain ProteinsInterleukin-4RAG-1 proteinReceptors, CCR4Receptors, CXCR3CCL17CD8 T cell memoryCD8 T cell primingiNKT cellsspatiotemporal kinetics

Identifiers

PMID31796596
PMCPMC6926036
OpenAlexW2992094578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.