Evidence map›Paper›PMID 31796589›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Smad7 in intestinal CD4

Steffen Haupeltshofer, Teresa Leichsenring, Sarah Berg, Xiomara Pedreiturria, Stephanie C Joachim, Iris Tischoff, Jan-Michel Otte, Tobias Bopp, Massimo C Fantini, Charlotte Esser and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Hypermethylation ofFrontiers in immunology · 2023
    Article
  12. Expression and function of Smad7 in autoimmune and inflammatory diseases.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
  13. The Nerves to Conduct a Multiple Sclerosis Crime Investigation.International journal of molecular sciences · 2021
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Differential Expression ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Steffen HaupeltshoferSt. Josef-Hospital, Department of Neurology, Ruhr-University Bochum, 44791 Bochum, Germany.
Teresa LeichsenringSt. Josef-Hospital, Department of Neurology, Ruhr-University Bochum, 44791 Bochum, Germany.
Sarah BergSt. Josef-Hospital, Department of Neurology, Ruhr-University Bochum, 44791 Bochum, Germany.
Xiomara PedreiturriaSt. Josef-Hospital, Department of Neurology, Ruhr-University Bochum, 44791 Bochum, Germany.
Stephanie C JoachimUniversity Eye Clinic, Experimental Eye Research Institute, Ruhr-University Bochum, 44892 Bochum, Germany.
Iris TischoffInstitut für Pathologie, Bergmannsheil, 44789 Bochum, Germany.
Jan-Michel OtteDepartment of Internal Medicine I, Klinikum Links der Weser, 28277 Bremen, Germany.
Tobias BoppInstitute for Immunology, Universitätsmedizin Mainz, 55131 Mainz, Germany.
Massimo C FantiniDepartment of Systems Medicine, University of Rome "Tor Vergata," 00133 Roma RM, Italy.
Charlotte EsserLeibniz-Institut für Umweltmedizinische Forschung, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Dieter WillboldInstitut für Physikalische Biologie, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Ralf GoldSt. Josef-Hospital, Department of Neurology, Ruhr-University Bochum, 44791 Bochum, Germany.
Simon FaissnerSt. Josef-Hospital, Department of Neurology, Ruhr-University Bochum, 44791 Bochum, Germany.
Ingo KleiterSt. Josef-Hospital, Department of Neurology, Ruhr-University Bochum, 44791 Bochum, Germany; ingo.kleiter@rub.de.ORCID 0000-0002-8249-4408
St. Josef-Hospital · DEBG University Hospital Bergmannsheil Bochum · DEForschungszentrum Jülich · DEHeinrich Heine University Düsseldorf · DEJohannes Gutenberg University Mainz · DEKlinikum Links der Weser · DERuhr University Bochum · DEUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental triggers acting at the intestinal barrier are thought to contribute to the initiation of autoimmune disorders. The transforming growth factor beta inhibitor Smad7 determines the phenotype of CD4

Indexed as

AnimalsAutoimmunityCD4-Positive T-LymphocytesCell DifferentiationCentral Nervous SystemDisease Models, AnimalEncephalomyelitisEncephalomyelitis, Autoimmune, ExperimentalGastrointestinal MicrobiomeGene Expression RegulationHumansImmune ToleranceInflammationIntestinesMiceMice, TransgenicSmad7 ProteinSMAD7 protein, humanSmad7 protein, mouseTransforming Growth Factor betagut–brain axismultiple sclerosisSmad7TGF-betaT helper cell

Identifiers

PMID31796589
PMCPMC6926056
OpenAlexW2992065324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.