Evidence map›Paper›PMID 31796587›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells.

Peter Csaba Huszthy, Ramakrishna Prabhu Gopalakrishnan, Johanne Tracey Jacobsen, Ole Audun Werner Haabeth, Geir Åge Løset, Ranveig Braathen, Karl Schenck, Anders Aune Tveita, Ludvig Andre Munthe, Bjarne Bogen

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Idiotype-specific CD4Nature communications · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Updates of the role of B-cells in ischemic stroke.Frontiers in cellular neuroscience · 2024
    Review
  6. Article
  7. Id-neoantigen vaccine induces therapeutic CD8Journal for immunotherapy of cancer · 2023
    Article
  8. Article
  9. Type III interferon drives thymic B cell activation and regulatory T cell generation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Frontiers in microbiology · 2023
    Article
  11. Article
  12. CD4Frontiers in immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Peter Csaba HuszthyInstitute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway; peter.csaba.huszthy@rr-research.no bjarne.bogen@medisin.uio.no.ORCID 0000-0003-0184-8989
Ramakrishna Prabhu GopalakrishnanInstitute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway.
Johanne Tracey JacobsenDepartment of Immunology, Oslo University Hospital, 0424 Oslo, Norway.
Ole Audun Werner HaabethDepartment of Immunology, Oslo University Hospital, 0424 Oslo, Norway.ORCID 0000-0002-1153-9250
Geir Åge LøsetDepartment of Biosciences, University of Oslo, N-0316 Oslo, Norway.ORCID 0000-0002-5257-8571
Ranveig BraathenDepartment of Immunology, Oslo University Hospital, 0424 Oslo, Norway.
Karl SchenckInstitute of Oral Biology, Faculty of Dentistry, University of Oslo, N-0316 Oslo, Norway.
Anders Aune TveitaDepartment of Immunology, Oslo University Hospital, 0424 Oslo, Norway.ORCID 0000-0002-0668-9262
Ludvig Andre MuntheInstitute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway.
Bjarne BogenInstitute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway; peter.csaba.huszthy@rr-research.no bjarne.bogen@medisin.uio.no.
Oslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes on B cells for recognition by CD4

Indexed as

AnimalsAntibodies, Anti-IdiotypicAutoimmune DiseasesB-LymphocytesCD4-Positive T-LymphocytesDisease Models, AnimalHistocompatibility Antigens Class IIImmunoglobulin GMiceMice, Inbred BALB CNeuropeptidesReceptors, Antigen, B-CellT-LymphocytesAntibodies, Anti-IdiotypicHistocompatibility Antigens Class IIImmunoglobulin GNeuropeptidespeptide VReceptors, Antigen, B-CellBCR ligation by antigenidiotype-driven T–B collaborationidiotypic peptide: MHCIIM315-like BCRV-gene modified mouse model

Identifiers

PMID31796587
PMCPMC6926052
OpenAlexW2994003829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.