Evidence map›Paper›PMID 31796544›Full record

ArticlemBio2019

A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae.

Giordan Kitts, Krista M Giglio, David Zamorano-Sánchez, Jin Hwan Park, Loni Townsley, Richard B Cooley, Benjamin R Wucher, Karl E Klose, Carey D Nadell, Fitnat H Yildiz and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Biofilm dispersal patterns revealed using far-red fluorogenic probes.bioRxiv : the preprint server for biology · 2024
    Article
  12. Review
  13. Journal of bacteriology · 2024
    Review
  14. A peptide-binding domain shared with an Antarctic bacterium facilitatesProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Mutational Analysis ofJournal of bacteriology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Giordan Kitts *Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Krista M Giglio *Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
David Zamorano-Sánchez *Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Jin Hwan ParkDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Loni TownsleyDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Richard B CooleyDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Benjamin R WucherDepartment of Biological Sciences, Dartmouth, Hanover, New Hampshire, USA.
Karl E KloseDepartment of Biology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, Texas, USA.
Carey D NadellDepartment of Biological Sciences, Dartmouth, Hanover, New Hampshire, USA.
Fitnat H YildizDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA fyildiz@ucsc.edu hs293@cornell.edu.
Holger SondermannDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA fyildiz@ucsc.edu hs293@cornell.edu.ORCID 0000-0003-2211-6234
University of California, Santa Cruz · USCornell University · USDartmouth College · USTexas Center for Infectious Disease · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Overall (pp. 40-62)P41GM103485 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2012 to 2018
$15.5M
Vibrio cholerae c-diGMP signaling: Motile to biofilm transition and transmissionR01AI102584 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2013 to 2023
$6.5M
Vibrio cholerae biofilms: structure, function, regulation and role in infectionR01AI114261 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2014 to 2024
$5.0M
Molecular mechanism regulating periplasmic proteolysis in bacterial pathogenesisR01GM123609 · NIGMS · CORNELL UNIVERSITY · PI O'TOOLE, GEORGE A., SONDERMANN, HOLGER · 2017 to 2020
$1.3M
BSLII Stationed Zeiss 880 Confocal Microscope with AiryscanS10OD023528 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2017 to 2017
$456k
NIAID NIH HHS R01 AI102584NIAID NIH HHS R01 AI114261NIGMS NIH HHS P20 GM113132NIGMS NIH HHS P30 GM124166NIGMS NIH HHS P41 GM103485NIGMS NIH HHS R01 GM123609NIH HHS S10 OD023528
6 · The paper itself

Abstract

The dinucleotide second messenger c-di-GMP has emerged as a central regulator of reversible cell attachment during bacterial biofilm formation. A prominent cell adhesion mechanism first identified in pseudomonads combines two c-di-GMP-mediated processes: transcription of a large adhesin and its cell surface display via posttranslational proteolytic control. Here, we characterize an orthologous c-di-GMP effector system and show that it is operational in

Indexed as

Adhesins, BacterialBacterial ProteinsBiofilmsCyclic GMPEscherichia coliGene Expression Regulation, BacterialSignal TransductionVibrio choleraeAdhesins, BacterialBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPadhesinsbiofilmscell signalingproteasesVibrio cholerae

Identifiers

PMID31796544
PMCPMC6890996
OpenAlexW2993738406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.