Evidence map›Paper›PMID 31796509›Full record

ArticleCMAJ open

The hepatitis C virus cascade of care in a Quebec provincial prison: a retrospective cohort study.

Nadine Kronfli, Camille Dussault, Marina B Klein, Bertrand Lebouché, Giada Sebastiani, Joseph Cox

Abstract read
In one paragraph

Article in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. National Hepatitis C estimates: Incidence, prevalence, undiagnosed proportion and treatment, Canada, 2019.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. HIPPOCRATESWorld journal of hepatology · 2020
    Article
  14. Article
  15. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nadine KronfliDivision of Infectious Diseases (Kronfli, Klein, Lebouché, Sebastiani, Cox), Department of Medicine, McGill University; Chronic Viral Illness Service (Kronfli, Klein, Lebouché, Sebastiani, Cox), McGill University; Research Institute of the McGill University Health Centre (Kronfli, Dussault, Klein, Lebouché, Sebastiani, Cox), Montréal, Que. nadine.kronfli@mcgill.ca.
Camille DussaultDivision of Infectious Diseases (Kronfli, Klein, Lebouché, Sebastiani, Cox), Department of Medicine, McGill University; Chronic Viral Illness Service (Kronfli, Klein, Lebouché, Sebastiani, Cox), McGill University; Research Institute of the McGill University Health Centre (Kronfli, Dussault, Klein, Lebouché, Sebastiani, Cox), Montréal, Que.
Marina B KleinDivision of Infectious Diseases (Kronfli, Klein, Lebouché, Sebastiani, Cox), Department of Medicine, McGill University; Chronic Viral Illness Service (Kronfli, Klein, Lebouché, Sebastiani, Cox), McGill University; Research Institute of the McGill University Health Centre (Kronfli, Dussault, Klein, Lebouché, Sebastiani, Cox), Montréal, Que.
Bertrand LebouchéDivision of Infectious Diseases (Kronfli, Klein, Lebouché, Sebastiani, Cox), Department of Medicine, McGill University; Chronic Viral Illness Service (Kronfli, Klein, Lebouché, Sebastiani, Cox), McGill University; Research Institute of the McGill University Health Centre (Kronfli, Dussault, Klein, Lebouché, Sebastiani, Cox), Montréal, Que.
Giada SebastianiDivision of Infectious Diseases (Kronfli, Klein, Lebouché, Sebastiani, Cox), Department of Medicine, McGill University; Chronic Viral Illness Service (Kronfli, Klein, Lebouché, Sebastiani, Cox), McGill University; Research Institute of the McGill University Health Centre (Kronfli, Dussault, Klein, Lebouché, Sebastiani, Cox), Montréal, Que.
Joseph CoxDivision of Infectious Diseases (Kronfli, Klein, Lebouché, Sebastiani, Cox), Department of Medicine, McGill University; Chronic Viral Illness Service (Kronfli, Klein, Lebouché, Sebastiani, Cox), McGill University; Research Institute of the McGill University Health Centre (Kronfli, Dussault, Klein, Lebouché, Sebastiani, Cox), Montréal, Que.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) microelimination efforts must target people in prison; however, although some inmates may qualify for treatment in provincial prisons, it may not be routinely provided. Our aim was to characterize the cascade of HCV care in Quebec's largest provincial prison.

methodsWe conducted a retrospective study of all HCV-related laboratory tests requested at the Établissement de détention de Montréal (men's prison with on-demand screening), between July 1, 2017, and June 30, 2018. We defined 8 HCV care cascade steps: 1) total sentenced inmates, 2) screened for HCV (via HCV antibody [HCV Ab]), 3) HCV Ab positive, 4) tested for HCV RNA, 5) HCV RNA positive, 6) linked to care, 7) HCV treatment initiated and 8) achieved sustained virologic response. We measured proportions of inmates at each step using denominator-numerator linkage. We also calculated the proportion screened among inmates with a sentence duration of at least 1 month, during which time screening should be feasible.

resultsOf the 4931 sentenced inmates, 344 (7%) were screened for HCV, of whom 38 (11%) were HCV Ab positive. Thirty-five (92%) of the 38 received HCV RNA testing, which showed positivity in 16 (46%). Ten (62%) of the 16 inmates were linked to care; treatment was initiated in 3 (30%), 2 of whom (67%) achieved a sustained virologic response. Among inmates with a sentence duration of at least 1 month (

interpretationA small proportion (7%) of men at a Canadian provincial prison with on-demand HCV testing were screened, and rates of treatment initiation were low in the absence of formal HCV cure pathways. To eliminate HCV in this subpopulation, opt-out HCV testing should be considered.

Identifiers

PMID31796509
PMCPMC6890491

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.