Evidence map›Paper›PMID 31796489›Full record

ArticleBMJ open2019

Uptake of routine viral load testing among people living with HIV and its implementation challenges in Yangon region of Myanmar: a mixed-methods study.

Khine Khine Thinn, Pruthu Thekkur, Nang Thu Thu Kyaw, Nyein Su Aye, Tin Maung Zaw, Pyae Soan, San Hone, Htun Nyunt Oo

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In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khine Khine ThinnDepartment of Public Health, Myanmar Ministry of Health and Sports, Yangon, Myanmar khinekhinethinn21@gmail.com.
Pruthu ThekkurCentre for Operational Research, International Union Against Tuberculosis and Lung Disease, Paris, France.
Nang Thu Thu KyawCentre for Operational Research, International Union Against Tuberculosis and Lung Disease, Mandalay, Myanmar.
Nyein Su AyeDepartment of Medical Research, Ministry of Health and Sports, Yangon, Myanmar.
Tin Maung ZawYangon Regional Public Health Department, Ministry of Health and Sports, Yangon, Myanmar.
Pyae SoanDepartment of Public Health, Myanmar Ministry of Health and Sports, Naypyidaw, Naypyidaw Union Territory, Myanmar.
San HoneDepartment of Public Health, Myanmar Ministry of Health and Sports, Naypyidaw, Naypyidaw Union Territory, Myanmar.
Htun Nyunt OoDepartment of Public Health, Myanmar Ministry of Health and Sports, Naypyidaw, Naypyidaw Union Territory, Myanmar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn 2017, Myanmar implemented routine viral load (VL) monitoring for assessing the response to antiretroviral therapy (ART) among people living with HIV (PLHIV). The performance of routine VL testing and implementation challenges has not yet assessed. We aimed to determine the uptake of VL testing and factors associated with it among PLHIV initiated on ART during 2017 in ART clinics of Yangon region and to explore the implementation challenges as perceived by the healthcare providers.

designAn explanatory mixed-methods study was conducted. The quantitative component was a cohort study, and the qualitative part was a descriptive study with in-depth interviews.

settingSix ART clinics operated by AIDS/sexually transmitted infection teams under the National AIDS Programme. PRIMARY OUTCOME MEASURES: (1) The proportion who underwent VL testing by 30 March 2019 and the proportion with virological suppression (plasma VL <1000 copies/mL); (2) association between patient characteristics and 'not tested' was assessed using log binomial regression and (3) qualitative codes on implementation challenges.

resultsOf the 567 PLHIV started on ART, 498 (87.8%) retained in care for more than 6 months and were eligible for VL testing. 288 (57.8%, 95% CI: 53.3% to 62.2%) PLHIV underwent VL testing, of which 263 (91.3%, 95% CI: 87.1% to 94.4%) had virological suppression. PLHIV with WHO clinical stage 4 had significantly higher rates of 'not being tested' for VL. Collection of sample for VL testing only twice a month, difficulties in sample collection and transportation, limited trained workforce, wage loss and out-of-pocket expenditure for patients due to added visits were major implementation challenges.

conclusionsThe VL test uptake was low, with only six out of ten PLHIV tested. The VL testing uptake needs to be improved by strengthening sample collection and transportation, adopting point-of-care VL tests, increasing trained workforce, providing compensation to patients for wage loss and travel costs for additional visits.

Indexed as

HIV InfectionsProcedures and Techniques UtilizationViral LoadAdultAnti-HIV AgentsCohort StudiesDrug MonitoringEvaluation Studies as TopicFemaleHealth Services Needs and DemandHumansMaleMedication AdherenceMyanmarPatient Acceptance of Health CareAnti-HIV AgentsAntiretroviral therapyoperational researchPLHIVSORT ITtreatment adherencevirological suppression

Identifiers

PMID31796489
PMCPMC6924823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.