Evidence map›Paper›PMID 31796154›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2019

Middle East respiratory syndrome coronavirus (MERS-CoV) neutralising antibodies in a high-risk human population, Morocco, November 2017 to January 2018.

Anass Abbad, Ranawaka Apm Perera, Latifa Anga, Abdellah Faouzi, Nhu Nguyen Tran Minh, Sk Md Mamunur Rahman Malik, Nadia Iounes, Abderrahmane Maaroufi, Maria D Van Kerkhove, Malik Peiris and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Phenotypic and genetic characterization of MERS coronaviruses from Africa to understand their zoonotic potential.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Observational
  10. Article
  11. Review
  12. Article
  13. Article
  14. The COVID-19 pandemic: implications for the cytology laboratory.Journal of the American Society of Cytopathology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Anass AbbadMedical Virology and BSL-3 Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Ranawaka Apm PereraSchool of Public Health, University of Hong-Kong, Hong Kong SAR, China.
Latifa AngaMedical Virology and BSL-3 Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Abdellah FaouziMedical Virology and BSL-3 Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Nhu Nguyen Tran MinhHealth Emergencies Programme, World Health Organization, Regional Office for the Eastern Mediterranean, Cairo, Egypt.
Sk Md Mamunur Rahman MalikHealth Emergencies Programme, World Health Organization, Regional Office for the Eastern Mediterranean, Cairo, Egypt.
Nadia IounesLaboratoire d'Ecologie et d'Environnement, Faculté des Sciences Ben M'Sik, Université Hassan II, Casablanca, Morocco.
Abderrahmane MaaroufiMedical Virology and BSL-3 Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Maria D Van KerkhoveHealth Emergencies Programme, World Health Organization, Geneva, Switzerland.
Malik PeirisSchool of Public Health, University of Hong-Kong, Hong Kong SAR, China.
Jalal NourlilMedical Virology and BSL-3 Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Institut Pasteur du Maroc · MAWorld Health Organization Regional Office for the Eastern Mediterranean · EGUniversity of Hassan II Casablanca · MAUniversity of Hong Kong · HKWorld Health Organization · CH

Funding

NIAID NIH HHS HHSN272201400006CWorld Health Organization 001
6 · The paper itself

Abstract

BackgroundMiddle East respiratory syndrome coronavirus (MERS-CoV) remains a major concern for global public health. Dromedaries are the source of human zoonotic infection. MERS-CoV is enzootic among dromedaries on the Arabian Peninsula, the Middle East and in Africa. Over 70% of infected dromedaries are found in Africa. However, all known zoonotic cases of MERS have occurred in the Arabian Peninsula with none being reported in Africa.AimWe aimed to investigate serological evidence of MERS-CoV infection in humans living in camel-herding areas in Morocco to provide insights on whether zoonotic transmission is taking place.MethodsWe carried out a cross sectional seroprevalence study from November 2017 through January 2018. We adapted a generic World Health Organization MERS-CoV questionnaire and protocol to assess demographic and risk factors of infection among a presumed high-risk population. ELISA, MERS-CoV spike pseudoparticle neutralisation tests (ppNT) and plaque neutralisation tests (PRNT) were used to assess MERS-CoV seropositivity.ResultsSerum samples were collected from camel slaughterhouse workers (n = 137), camel herders (n = 156) and individuals of the general population without occupational contact with camels but living in camel herding areas (n = 186). MERS-CoV neutralising antibodies with ≥ 90% reduction of plaque numbers were detected in two (1.5%) slaughterhouse workers, none of the camel herders and one individual from the general population (0.5%).ConclusionsThis study provides evidence of zoonotic transmission of MERS-CoV in Morocco in people who have direct or indirect exposure to dromedary camels.

Indexed as

Occupational ExposureAbattoirsAdolescentAdultAgedAged, 80 and overAnimalsAntibodies, NeutralizingAntibodies, ViralCamelusCoronavirus InfectionsCross-Sectional StudiesDisease ReservoirsEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GRNA, ViraldromedariesMERS-CoVMiddle East Respiratory Syndrome CoronavirusMoroccotransmissionzoonosis

Identifiers

PMID31796154
PMCPMC6891945
OpenAlexW2991640369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.