Evidence map›Paper›PMID 31796058›Full record

ArticleMolecular cancer2019

Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts.

Jing Kong, Hongzhu Tian, Fuyin Zhang, Zebing Zhang, Jiao Li, Xue Liu, Xiancheng Li, Jing Liu, Xiaojie Li, Dong Jin and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 241 citations in OpenAlex.

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  6. Conversion therapy using transarterial chemoembolization plus tislelizumab for unresectable hepatocellular carcinoma: effects on tumor necrosis and anti-tumor immune response.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Jing KongDepartment of Oral Pathology, College of Stomatology, Dalian Medical University, West Section No. 9, South Road of Lvshun, Dalian, 116044, China.
Hongzhu TianDepartment of Oral Pathology, College of Stomatology, Dalian Medical University, West Section No. 9, South Road of Lvshun, Dalian, 116044, China.
Fuyin ZhangDepartment of Oral Surgery, the Second Affiliated Hospital, Dalian Medical University, Dalian, China.
Zebing ZhangDepartment of Oral Pathology, College of Stomatology, Jilin University, Changchun, China.
Jiao LiDepartment of Oral Pathology, College of Stomatology, Dalian Medical University, West Section No. 9, South Road of Lvshun, Dalian, 116044, China.
Xue LiuDepartment of Oral Pathology, College of Stomatology, Dalian Medical University, West Section No. 9, South Road of Lvshun, Dalian, 116044, China.
Xiancheng LiDepartment of Urology, the Second Affiliated Hospital, Dalian Medical University, Dalian, China.
Jing LiuSino-UK Regenerative Medicine Center, the First Affiliated Hospital, Dalian Medical University, Dalian, China.
Xiaojie LiDepartment of Oral Pathology, College of Stomatology, Dalian Medical University, West Section No. 9, South Road of Lvshun, Dalian, 116044, China.
Dong JinDepartment of Oral Pathology, College of Stomatology, Dalian Medical University, West Section No. 9, South Road of Lvshun, Dalian, 116044, China.
Xuesong YangDepartment of Biochemistry and Molecular Biology, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian Medical University, Dalian, China.
Bo SunDepartment of Oral Surgery, the Second Affiliated Hospital, Dalian Medical University, Dalian, China.
Tao GuoDepartment of Thoracic Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Yong LuoFaculty of Chemical, Environmental and Biological Science and Technology, Dalian Technology University, Dalian, China.
Yao LuDepartment of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Bingcheng LinFaculty of Chemical, Environmental and Biological Science and Technology, Dalian Technology University, Dalian, China.
Tingjiao LiuDepartment of Oral Pathology, College of Stomatology, Dalian Medical University, West Section No. 9, South Road of Lvshun, Dalian, 116044, China. tingjiao@dlmedu.edu.cn.ORCID 0000-0001-5850-789X
Dalian Medical University · CNDalian Institute of Chemical Physics · CNDalian University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCarcinoma-associated fibroblasts (CAFs) have been known to promote cancer progression by modifying the primary tumor microenvironment. We aimed to elucidate the intercellular communication between CAFs and secondary organs in salivary adenoid cystic carcinoma (SACC) metastasis.

methodsPre-metastatic and metastatic animal models of SACC were established using extracellular vesicles (EVs) from CAFs and SACC cells. Lung fibroblasts (LFs) were treated with EVs and their transcriptomic alterations were identified by RNA sequencing. ITRAQ were performed to analyze EV cargos. TC I-15 was used to inhibit EV uptake by LFs and SACC lung metastasis in vivo.

resultsHere, we show that CAF EVs induced lung pre-metastatic niche formation in mice and consequently increased SACC lung metastasis. The pre-metastatic niche induced by CAF EVs was different from that induced by SACC EVs. CAF EVs presented a great ability for matrix remodeling and periostin is a potential biomarker characterizing the CAF EV-induced pre-metastatic niche. We found that lung fibroblast activation promoted by CAF EVs was a critical event at the pre-metastatic niche. Integrin α2β1 mediated CAF EV uptake by lung fibroblasts, and its blockage by TC I-15 prevented lung pre-metastatic niche formation and subsequent metastasis. Plasma EV integrin β1 was considerably upregulated in the mice bearing xenografts with high risk of lung metastasis.

conclusionsWe demonstrated that CAF EVs participated in the pre-metastatic niche formation in the lung. Plasma EV integrin β1 might be a promising biomarker to predict SACC metastasis at an early stage. An integrated strategy targeting both tumor and stromal cells is necessary to prevent SACC metastasis.

Indexed as

Tumor MicroenvironmentAnimalsCancer-Associated FibroblastsCell Line, TumorDisease Models, AnimalExtracellular MatrixExtracellular VesiclesGene Expression ProfilingHumansIntegrin alpha2beta1Lung NeoplasmsMiceModels, BiologicalNeoplasm MetastasisSignal TransductionTransforming Growth Factor betaIntegrin alpha2beta1Transforming Growth Factor betaCarcinoma-associated fibroblastExtracellular vesiclesLung metastasisPre-metastatic niche

Identifiers

PMID31796058
PMCPMC6892147
OpenAlexW2994535290

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.