Evidence map›Paper›PMID 31796025›Full record

ArticleMalaria journal2019

Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial.

Catherine E Oldenburg, Abdou Amza, Gretchen Cooley, Boubacar Kadri, Beido Nassirou, Benjamin F Arnold, Philip J Rosenthal, Kieran S O'Brien, Sheila K West, Robin L Bailey and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00792922 (Research to Programs for Trachoma Elimination), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00792922 phase4completednot on this map

Research to Programs for Trachoma Elimination: Antibiotic Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2008 to 2014Enrolled128ConditionsTrachomaArmsAzithromycin
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Catherine E OldenburgFrancis I Proctor Foundation, University of California, San Francisco, San Francisco, CA, USA. catherine.oldenburg@ucsf.edu.ORCID http://orcid.org/0000-0002-0763-399X
Abdou AmzaProgramme FSS/Université Abdou Moumouni de Niamey, Programme Nationale des Soins Oculaire, Niamey, Niger.
Gretchen CooleyDivision of Parasitic Diseases and Malaria, Centers for Disease Prevention and Control, Atlanta, GA, USA.
Boubacar KadriProgramme FSS/Université Abdou Moumouni de Niamey, Programme Nationale des Soins Oculaire, Niamey, Niger.
Beido NassirouProgramme FSS/Université Abdou Moumouni de Niamey, Programme Nationale des Soins Oculaire, Niamey, Niger.
Benjamin F ArnoldDepartment of Epidemiology, University of California, Berkeley, Berkeley, CA, USA.
Philip J RosenthalDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kieran S O'BrienFrancis I Proctor Foundation, University of California, San Francisco, San Francisco, CA, USA.
Sheila K WestDana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Robin L BaileyClinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Travis C PorcoFrancis I Proctor Foundation, University of California, San Francisco, San Francisco, CA, USA.
Jeremy D KeenanFrancis I Proctor Foundation, University of California, San Francisco, San Francisco, CA, USA.
Thomas M LietmanFrancis I Proctor Foundation, University of California, San Francisco, San Francisco, CA, USA.
Diana L MartinDivision of Parasitic Diseases and Malaria, Centers for Disease Prevention and Control, Atlanta, GA, USA.
University of California, San Francisco · USUniversité Abdou Moumouni · NEDivision of Parasitic Diseases and Malaria · USJohns Hopkins University · USLondon School of Hygiene & Tropical Medicine · GBUniversity of California, Berkeley · US

Funding

The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

backgroundBiannual mass azithromycin administration to preschool children reduces all-cause mortality, but the mechanism for the effect is not understood. Azithromycin has activity against malaria parasites, and malaria is a leading cause of child mortality in the Sahel. The effect of biannual versus annual azithromycin distribution for trachoma control on serological response to merozoite surface protein 1 (MSP-1

methodsMarkers of malaria exposure were measured in two arms of a factorial randomized controlled trial designed to evaluate targeted biannual azithromycin distribution to children under 12 years of age compared to annual azithromycin to the entire community for trachoma control (N = 12 communities per arm). Communities were treated for 36 months (6 versus 3 distributions). Dried blood spots were collected at 36 months among children ages 1-5 years, and MSP-1

resultsAntibody results were available for 991 children. MSP-1

conclusionsTargeted biannual azithromycin distribution was associated with lower malaria seroprevalence compared to that in a population that received annual distribution. Trial Registration Clinicaltrials.gov NCT00792922.

Indexed as

AntimalarialsAzithromycinChild, PreschoolFemaleHumansInfantMalariaMaleMass Drug AdministrationMerozoite Surface Protein 1NigerPrevalenceSeroepidemiologic StudiesTime FactorsAntimalarialsAzithromycinMerozoite Surface Protein 1AzithromycinMalariaMass drug administrationNiger

Identifiers

PMID31796025
PMCPMC6889587
OpenAlexW2992004501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.