ArticleBMC veterinary research2019
Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study.
Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Computed tomography versus magnetic resonance imaging for the perioperative management of acute thoracolumbar intervertebral disc extrusion in non-ambulatory chondrodystrophic dogs.Veterinary surgery : VS · 2026Article
- A Comparative Analysis of Clinical Presentation, Prognosis and Outcomes in Paralytic Dogs with a Compressive and a Contusive Intervertebral Disc Disease.Veterinary sciences · 2025Article
- Characterization of risk factors for early ambulation in paraplegic dogs with absent pain perception undergoing decompressive surgery for thoracolumbar intervertebral disk extrusions.Frontiers in veterinary science · 2024Article
- A case series of 37 surgically managed, paraplegic, deep pain negative French bulldogs, with thoracolumbar intervertebral disc extrusion, from two English referral centres.Veterinary record open · 2023Article
- Case report: Clinical and pathological findings in a canine patient with intervertebral disk extrusion resembling progressive myelomalacia.Frontiers in veterinary science · 2023Article
- Significance of intramedullary T2Frontiers in veterinary science · 2023Article
- Diagnostic and Treatment of Spinal Fracture and Luxation in Italian Wolves (Animals : an open access journal from MDPI · 2022Article
- ACVIM consensus statement on diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion.Journal of veterinary internal medicine · 2022Article
- Outcomes of extensive hemilaminectomy with durotomy on dogs with presumptive progressive myelomalacia: a retrospective study on 34 cases.BMC veterinary research · 2020Article
- Prognostic Factors in Canine Acute Intervertebral Disc Disease.Frontiers in veterinary science · 2020Review
- Case Report: Intramedullary Intervertebral Disk Extrusion in a Cat: Clinical, Computed Tomographic, High-Field Magnetic Resonance Imaging, and Outcome Findings.Frontiers in veterinary science · 2020Article
- Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury.Frontiers in veterinary science · 2020Review
- Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study.BMC veterinary research · 2019Article
- Case-Control Investigation of Association of Clinician-Determined Variables With Progressive Myelomalacia After Acute Thoracolumbar Disc Extrusion in Dogs.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundProgressive myelomalacia (PMM) is a usually fatal complication of acute intervertebral disc extrusion (IVDE) in dogs but its risk factors are poorly understood. The objective of this retrospective case-control study was to identify risk factors for PMM by comparing dogs with complete sensorimotor loss following IVDE that did and did not develop the disease after surgery. We also investigated whether any risk factors for PMM influenced return of ambulation. Medical records of client-owned dogs with paraplegia and loss of pain perception that underwent surgery for IVDE from 1998 to 2016, were reviewed. Dogs were categorized as PMM yes or no based on clinical progression or histopathology. Walking outcome at 6 months was established. Signalment, onset and duration of signs (categorized), steroids, non-steroidal anti-inflammatory drugs (yes or no), site of IVDE (lumbar intumescence or thoracolumbar) and longitudinal extent of IVDE were retrieved and their associations with PMM and walking outcome were examined using logistic regression.
resultsOne hundred and ninety seven dogs were included, 45 with and 152 without PMM. A 6-month-outcome was available in 178 dogs (all 45 PMM dogs and 133 control dogs); 86 recovered walking (all in the control group). Disc extrusions at the lumbar intumescence were associated with PMM (p = 0.01, OR: 3.02, CI: 1.3-7.2). Surgery performed more than 12 h after loss of ambulation was associated with PMM (OR = 3.4; CI = 1.1-10.5, p = 0.03 for 12-24 h and OR = 4.6; CI = 1.3-16.6, p = 0.02 for the > 24 h categories when compared with the ≤12 h category). Treatment with corticosteroids was negatively associated with PMM (OR: 3.1; CI: 1.3-7.6, p = 0.01). The only variable to affect walking outcome was longitudinal extent of IVDE (OR = 2.6; CI = 1.3-5.3, p = 0.006).
conclusionDogs with lumbar intumescence IVDE are at increased risk of PMM. Timing of surgery and corticosteroid use warrant further investigations. PMM and recovery of walking are influenced by different factors.
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