ArticleBMC geriatrics2019
Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China.
Article in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 84 citations in OpenAlex.
- An explainable online frailty prediction model for community-dwelling older adults based on machine learning algorithms: a cross-sectional study based on retrospective health data.Annals of medicine · 2026Article
- Latent biochemical phenotypes delineate divergent health trajectories in older adults.npj aging · 2026Article
- Article
- Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments.Aging cell · 2025Article
- A Risk Warning Model for Anemia Based on Facial Visible Light Reflectance Spectroscopy: Cross-Sectional Study.JMIR medical informatics · 2025Article
- The mediating effect of handgrip strength on the association between sleep duration and basal metabolic rate in middle-aged and older adults: evidence from the China health and retirement longitudinal study.Frontiers in public health · 2025Article
- Preoperative Anaemia Increases the Likelihood of 1-Year Mortality After Hip Fracture.Advances in orthopedics · 2025Article
- Development and validation of a frailty risk prediction model in patients with peripheral artery disease.Frontiers in surgery · 2025Article
- Intake of vegetables and fruits at midlife and the risk of physical frailty in later life.The journal of nutrition, health & aging · 2024Article
- Independent and combined associations of depression and cognitive impairment with frailty in oldest-old adults.BMC psychology · 2024Article
- Reliability, validity and minimal detectable change of the Chinese Version of the Assessment of Physical Activity in Frail Older People (APAFOP-C).BMC geriatrics · 2024Article
- Postoperative anaemia increases unplanned readmission: an international prospective cohort study of patients undergoing major abdominal surgery.The British journal of surgery · 2024Article
- Relationship between anemia and its correlates and cognitive function in Chinese patients with chronic schizophrenia: A large cross-sectional study.Schizophrenia research. Cognition · 2024Article
- The temporal trends of prevalence and years lived with disability of anaemia in China, Japan, and South Korea, from 1990 to 2021: Results from the Global Burden of Disease Study 2021.Journal of global health · 2024Article
- Relationship between hemoglobin and grip strength in older adults: the ActiFE study.Aging clinical and experimental research · 2024Article
- Predictors of mortality in chronic subdural hematoma evacuation.Neurosurgical review · 2023Article
- Anemia and frailty in the aging population: implications of dietary fiber intake (findings of the US NHANES from 2007-2018).BMC geriatrics · 2023Article
- Associations of dietary, sociodemographic, and anthropometric factors with anemia among the Zhuang ethnic adults: a cross-sectional study in Guangxi Zhuang Autonomous Region, China.BMC public health · 2023Article
- Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundAnemia and frailty contribute to poor health outcomes in older adults; however, most current research in lower income countries has concentrated on anemia or frailty alone rather than in combination. The aim of the present study was to investigate the association between anemia and frailty in community-dwelling adults aged 50 years and older in China.
methodsThe study population was sourced from the 2007/10 SAGE China Wave 1. Anemia was defined as hemoglobin less than 13 g/dL for men and less than 12 g/dL for women. A Frailty Index (FI) was compiled to assess frailty. The association between anemia and frailty was evaluated using a 2-level hierarchical logistic model.
resultsThe prevalence of anemia was 31.0% (95%CI: 28.4, 33.8%) and frailty 14.7% (95%CI: 13.5, 16.0%). In the univariate regression model, presence of anemia was significantly associated with frailty (OR = 1.62, 95% CI: 1.39, 1.90) and the effect remained consistent after adjusting for various potential confounding factors including age, gender, residence, education, household wealth, fruit and vegetable intake, tobacco use, alcohol comsumption and physical activity (adjusted OR = 1.31, 95% CI:1.09, 1.57). Each 1 g/dL increase in hemoglobin concentration was associated with 4% decrease in the odds of frailty after adjusting for several confounding variables (adjusted OR = 0.96, 95% CI: 0.93, 0.99).
conclusionAnemia and low hemoglobin concentrations were significantly associated with frailty. Therefore, health care professionals caring for older adults should increase screening, assessment of causes and treatment of anemia as one method of avoiding, delaying or even reversing frailty.
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