Observational studyBMC emergency medicine2019
The prognostic value of red blood cell distribution width in patients with suspected infection in the emergency department.
Observational study in BMC emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- Article
- Article
- Article
- Designing a Virtual Hospital-at-Home Intervention for Patients with Infectious Diseases: A Data-Driven Approach.Journal of clinical medicine · 2024Article
- Association between platelet-to-red cell distribution width ratio and all-cause mortality in critically ill patients with non-traumatic cerebral hemorrhage: a retrospective cohort study.Frontiers in neurology · 2024Article
- Association of red blood cell distribution width with hospital admission and in-hospital mortality across all-cause adult emergency department visits.JAMIA open · 2023Article
- Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice.Communications biology · 2023Article
- Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions.Journal of clinical medicine · 2023Article
- Added diagnostic value of routinely measured hematology variables in diagnosing immune checkpoint inhibitor mediated toxicity in the emergency department.Cancer medicine · 2023Article
- A machine learning approach using endpoint adjudication committee labels for the identification of sepsis predictors at the emergency department.BMC emergency medicine · 2022Article
- Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital.Pathogens (Basel, Switzerland) · 2022Article
- Factors associated with in-hospital mortality in adult sepsis with Escherichia coli infection.BMC infectious diseases · 2022Article
- Hematological Ratios Are Associated with Acute Kidney Injury and Mortality in Patients That Present with Suspected Infection at the Emergency Department.Journal of clinical medicine · 2022Article
- Observational
- Code status documentation at admission in COVID-19 patients: a descriptive cohort study.BMJ open · 2021Article
- Significance of RDW in predicting mortality in COVID-19-An analysis of 622 cases.International journal of laboratory hematology · 2021Article
- Association Between Red Cell Distribution Width and Hospital Mortality in Patients with Sepsis.The Journal of international medical research · 2021Observational
- Retrospective study on the possible existence of a treatment paradox in sepsis scores in the emergency department.BMJ open · 2021Observational
- Red blood cell distribution width and outcome in trauma patients.Journal of osteopathic medicine · 2021Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is a potential life threatening dysregulated immune response to an infection, which can result in multi-organ failure and death. Unfortunately, good prognostic markers are lacking in patients with suspected infection to identify those at risk. Red blood cell distribution width (RDW) is a common and inexpensive hematologic laboratory measurement associated with adverse prognosis in multiple diseases. The aim of this study was to determine the prognostic value of RDW for mortality and early clinical deterioration in patients with a suspected infection in the emergency department.
methodsIn this single center prospective observational cohort study, consecutive patients with suspected infection presenting for internal medicine in the emergency department between September 2016 and March 2018 were included. For prognostic validation of bedside sepsis scores and RDW receiver operating characteristics were generated. Association between RDW and mortality and ICU admission was analyzed univariate and in a multivariate logistic regression model.
results1046 patients were included. In multivariate analyses, RDW was significantly associated with 30-day mortality (OR 1.15, 95% CI: 1.04-1.28) and early clinical deterioration (OR 1.09, 95% CI: 1.00-1.18). For 30-day mortality RDW had an AUROC of 0.66 (95% CI 0.59-0.72). Optimal cut-off value for RDW 2 was 12.95%. For early clinical deterioration RDW had an AUROC of 0.59 (95% CI 0.54-0.63) with an optimal cut-off value of 14.48%.
conclusionsRDW was found to be a significant independent prognostic factor of 30-day mortality and early clinical deterioration in patients with suspected infection.. Therefore it can be a used as an extra marker besides bedside sepsis scores in identifying patients at risk for worse outcome in patients with suspected infection.
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