ReviewOpen biology2019
Lignin biosynthesis: old roads revisited and new roads explored.
Review in Open biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
114 citing papers in PubMed, 262 citations in OpenAlex.
- Pan-genome characterization of the maize 4CL gene family and its dynamic responses to abiotic stress.Plant molecular biology · 2026Article
- Exogenous Application of Cellulose-Based Materials for Improved Plant Fitness.International journal of molecular sciences · 2026Review
- LignAmb25: A comprehensive AMBER force field addressing lignin's structural and chemical diversity.Biophysical journal · 2026Article
- Simultaneous Overexpression of FERULOYL-CoA 6'-HYDROXYLASE 1 and COUMARIN SYNTHASE Leads to Coumarin-Enriched Lignin and Improved Saccharification in Greenhouse- and Field-Grown Poplar.Plant biotechnology journal · 2026Article
- From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Ancient origins of alkaloid biosynthesis in medicinal clubmosses.bioRxiv : the preprint server for biology · 2026Article
- Conserved 4-coumarate 3-hydroxylase/ascorbate peroxidase bifunctionality coordinates lignin deposition and plant growth in Brachypodium and Populus.Plant physiology · 2026Article
- Genome-Wide Identification of the R2R3-MYB Gene Family Members in Masson Pine and the Regulation of Secondary Cell Wall Formation and Lignin Biosynthesis byPlants (Basel, Switzerland) · 2026Article
- Precursor-Dependent Routing of Aromatic Amino Acids Determines Lignin Structure in Grasses by Sensitivity-Enhanced Solid-State NMR.Journal of the American Chemical Society · 2026Article
- Genome-wide characterization of the LAC gene family in five fern species reveals evolutionary diversification and putative roles in lignin biosynthesis in Alsophila spinulosa.BMC plant biology · 2026Article
- Exogenous NO enhances drought tolerance in alfalfa via the lignin synthesis pathway.BMC genomics · 2026Article
- CESA7 and microtubules pattern complex secondary cell walls in explosive fruit of Cardamine hirsuta.The Plant cell · 2026Article
- Precursor-Dependent Routing of Aromatic Amino Acids Determines Lignin Structure in Grasses by Sensitivity-Enhanced Solid-State NMR.bioRxiv : the preprint server for biology · 2026Article
- Molecular mechanisms of root expansion in medicinal plants.Frontiers in plant science · 2026Review
- Habitat suitability and active component responses ofFrontiers in plant science · 2026Article
- Flavescence dorée phytoplasma infection represses the transcription of the lignin pathway inFrontiers in plant science · 2026Article
- LigninFit: Stochastic Simulation Software for the Prediction and Analysis of Experimentally Observed Lignin Molecules.Computational and structural biotechnology journal · 2026Article
- Integrative transcriptomic and proteomic analysis reveals the regulatory mechanisms underlying oilseed rape resistance to Leptosphaeria biglobosa.Frontiers in plant science · 2026Article
- Boosting lignocellulosic bioethanol production: fermentation of corn stalk using a lignin-reduced brown midrib 2 maize mutant.Biotechnology for biofuels and bioproducts · 2025Article
- A Role for the Plastidial GPT2 Translocator in the Modulation of Lignin Biosynthesis.Plant, cell & environment · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lignin is a major component of secondarily thickened plant cell walls and is considered to be the second most abundant biopolymer on the planet. At one point believed to be the product of a highly controlled polymerization procedure involving just three potential monomeric components (monolignols), it is becoming increasingly clear that the composition of lignin is quite flexible. Furthermore, the biosynthetic pathways to the major monolignols also appear to exhibit flexibility, particularly as regards the early reactions leading to the formation of caffeic acid from coumaric acid. The operation of parallel pathways to caffeic acid occurring at the level of shikimate esters or free acids may help provide robustness to the pathway under different physiological conditions. Several features of the pathway also appear to link monolignol biosynthesis to both generation and detoxification of hydrogen peroxide, one of the oxidants responsible for creating monolignol radicals for polymerization in the apoplast. Monolignol transport to the apoplast is not well understood. It may involve passive diffusion, although this may be targeted to sites of lignin initiation/polymerization by ordered complexes of both biosynthetic enzymes on the cytosolic side of the plasma membrane and structural anchoring of proteins for monolignol oxidation and polymerization on the apoplastic side. We present several hypothetical models to illustrate these ideas and stimulate further research. These are based primarily on studies in model systems, which may or may not reflect the major lignification process in forest trees.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.