Evidence map›Paper›PMID 31795903›Full record

ArticleStroke2020

Association of Baseline Cardiac Troponin With Acute Myocardial Infarction in Stroke Patients Presenting Within 4.5 Hours.

Yuyao Sun, Małgorzata M Miller, Shadi Yaghi, Brian Silver, Nils Henninger

Abstract read
In one paragraph

Article in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Observational
  5. Prevalence of myocardial injury in patients after acute ischaemic stroke according to standard criteria.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuyao SunFrom the Department of Neurology (Y.S., B.S., N.H.), University of Massachusetts Medical School, Worcester.
Małgorzata M MillerDepartment of Neurology, University of Pittsburgh Medical Center, PA (M.M.M.).
Shadi YaghiDepartment of Neurology, New York University Langone Health, Brooklyn (S.Y.).
Brian SilverFrom the Department of Neurology (Y.S., B.S., N.H.), University of Massachusetts Medical School, Worcester.
Nils HenningerFrom the Department of Neurology (Y.S., B.S., N.H.), University of Massachusetts Medical School, Worcester.

Funding

Reducing Brain Injury After Focal Ischemia Using a Nitric Oxide-Neutral Oxygen CarrierR44NS076272 · NINDS · OMNIOX, INC. · PI KRTOLICA, ANA, WINGER, JONATHAN A · 2016 to 2017
$2.3M
Inhibiting axon degeneration in a mouse model of acute brain injury through deletion of Sarm1K08NS091499 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS · 2016 to 2020
$919k
NINDS NIH HHS K08 NS091499NINDS NIH HHS R44 NS076272
6 · The paper itself

Abstract

Background and Purpose- American Heart Association guidelines recommend obtaining baseline troponin in all patients with acute ischemic stroke. Yet, there is a paucity of data on the prevalence of baseline troponin elevation and specifically its diagnostic yield for acute myocardial infarction (AMI) in patients presenting within the time window for thrombolysis. Methods- We retrospectively analyzed 1072 consecutive patients admitted for acute ischemic stroke or transient ischemic attack, who presented within 4.5 hours of last known well (LKW). Patients who had baseline cardiac troponin I (bcTnI) obtained within 72 hours from LKW (n=525) were included in the study. Multivariable logistic regression was conducted to determine factors independently related to an elevated bcTnI (>0.04 ng/mL). We calculated the area under receiver operator curves, sensitivity, and specificity, to determine the diagnostic accuracy of (i) the bcTnI for AMI stratified by the time to assessment and (ii) the best time cutoff for obtaining bcTnI. Results- Among included subjects, the median time from LKW to the bcTnI was 3.8 hours and 113 (21.5%) subjects had an elevated bcTnI. Assessment of bcTnI within 4.5 hours from LKW was significantly more often associated with normal values as compared to assessment between 4.5 and 72 hours (61.7% versus 38.3%;

Indexed as

AgedBiomarkersBrain IschemiaFemaleHumansMaleMiddle AgedMyocardial InfarctionRetrospective StudiesSensitivity and SpecificityStrokeTime FactorsTroponinBiomarkersTroponinmyocardial infarctionprevalencesensitivity and specificitystrokethrombolysistimetroponin

Identifiers

PMID31795903
PMCPMC6928425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.