ReviewInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2019
Temperature as a modulator of the gut microbiome: what are the implications and opportunities for thermal medicine?
Review in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Experimental temperatures shape host microbiome diversity and composition.Global change biology · 2023Pooled it
- Climate Change, Epigenetics, Microbiota, and Health.International journal of environmental research and public health · 2026Review
- Narrative review on microbiota and sepsis: the host's betrayal?Internal and emergency medicine · 2026Review
- The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health.Allergy · 2026Article
- Enhancing Cancer Therapy with Hyperthermia: Synergistic Effects with Natural Compounds and Conventional Treatments.International journal of molecular sciences · 2026Review
- Fungal Microbiome Within Lichen as a Potential Bioindicator of Climate Change: Insights from Transplant Field Study.Mycobiology · 2026Article
- Ignoring the planet: A critical blind spot for research on ageing.Journal of internal medicine · 2025Review
- The Influence of Seasonal Variations in Clinical Trials Based on Gut Microbiota Studies.Microorganisms · 2025Review
- Physiological Conditions, Bioactive Ingredients, and Drugs Stimulating Non-Shivering Thermogenesis as a Promising Treatment Against Diabesity.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Ramping up the Heat: Induction of Systemic and Pulmonary Immune Responses and Metabolic Adaptations in Mice.bioRxiv : the preprint server for biology · 2025Article
- Exploring the Skin Benefits of Extremophilic Postbiotics fromMicroorganisms · 2025Article
- Effects of Climate Change on the Immune System: A Narrative Review.Health science reports · 2025Article
- Culture-Independent Species-Level Taxonomic and Functional Characterisation of Bacteroides, the Core Bacterial Genus Within Reptile Guts.Molecular ecology · 2025Article
- Harnessing Evolution and Biomimetics to Enhance Planetary Health: Kidney Insights.Journal of the American Society of Nephrology : JASN · 2025Review
- Probiotics in Poultry: Unlocking Productivity Through Microbiome Modulation and Gut Health.Microorganisms · 2025Review
- A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Parabacteroides distasonis regulates the infectivity and pathogenicity of SVCV at different water temperatures.Microbiome · 2024Article
- Monomodular and multifunctional processive endocellulases: implications for swine nutrition and gut microbiome.Animal microbiome · 2024Review
- Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study.Frontiers in cellular and infection microbiology · 2024Article
- Gut microbiome diversity in a febrile seizure mouse model.Encephalitis (Seoul, Korea) · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
There is substantial research being conducted on the relationships between the gut microbiome, the immune response and health and disease. Environmental temperature and heat stress are known to modify the gut microbiome. Changes in core temperature have been linked, in multiple phyla, to altered microbiome composition and function. This raises the question of whether local/regional or whole body thermal therapies which target tumors in the abdomen, peritoneal cavity, or pelvis influence the gut microbiome. To date, there is little information on whether thermal therapy exerts positive or negative effects on the microbiome. This is an intriguing question since there is growing interest in the immunological impact of various thermal therapies. The goal of this brief review is to highlight research on how environmental conditions, particularly temperature (internal as well as external temperatures) influences the gut microbiome. Given the potential for temperature shifts to modulate gut microbe function and composition, it is likely that various forms of thermal therapy, including hyperthermic intraperitoneal chemotherapy (HIPEC), deep regional, and whole body hyperthermia influence the microbiome in ways that are currently not appreciated. More research is needed to determine whether thermal therapy induced changes in the microbiome occur, and whether they are beneficial or detrimental to the host. Currently, although approaches to microbiome modification such as dietary intervention, fecal transfer, probiotics and prebiotics are being developed, the potential of temperature manipulation has, as yet, not been explored. Therefore, new research could reveal whether perturbations of the microbiome composition that have negative health consequences (dysbiosis) could be an important target for treatment by thermal medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.