Evidence map›Paper›PMID 31795515›Full record

ArticleJournal of clinical medicine2019

AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis.

Raela B Ridley, Brianna M Young, Jieun Lee, Erin Walsh, Chulbul M Ahmed, Alfred S Lewin, Cristhian J Ildefonso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raela B RidleyDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Brianna M YoungDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Jieun LeeDepartment of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Erin WalshDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Chulbul M AhmedDepartment of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Alfred S LewinDepartment of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Cristhian J IldefonsoDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL 32610, USA.

Funding

Testing Gene Therapy in Models of Geographic AtrophyR01EY026268 · NEI · UNIVERSITY OF FLORIDA · PI LEWIN, ALFRED S · 2016 to 2020
$2.6M
Bright Focus Foundation M2017126NEI NIH HHS 5R01EY026268NEI NIH HHS R01 EY026268Research to Prevent Blindness Unrestricted Departmental Grant
6 · The paper itself

Abstract

Uveoretinitis is an ocular autoimmune disease caused by the activation of autoreactive T- cells targeting retinal antigens. The myxoma M013 gene is known to block NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) and inflammasome activation, and its gene delivery has been demonstrated to protect the retina against lipopolysaccharide (LPS)-induced uveitis. In this report we tested the efficacy of M013 in an experimental autoimmune uveoretinitis (EAU) mouse model. B10RIII mice were injected intravitreally with AAV (adeno associated virus) vectors delivering either secreted GFP (sGFP) or sGFP-TatM013. Mice were immunized with interphotorecptor retinoid binding protein residues 161-180 (IRBP

Indexed as

adeno-associated virusautoimmuneM013myxomauveitis

Identifiers

PMID31795515
PMCPMC6947576

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.