Evidence map›Paper›PMID 31795225›Full record

ArticleInternational journal of molecular sciences2019

Biomimetic Synthesis of Nanocrystalline Hydroxyapatite Composites: Therapeutic Potential and Effects on Bone Regeneration.

Chih-Hsiang Fang, Yi-Wen Lin, Feng-Huei Lin, Jui-Sheng Sun, Yuan-Hung Chao, Hung-Ying Lin, Zwei-Chieng Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Biological and Mechanical Comparison of Eggshell-Derived Hydroxyapatite, Calcium Hydroxide, and Mineral Trioxide Aggregate.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Fish: a new xenograft source for maxillary sinus lifting.Journal of applied oral science : revista FOB · 2024
    Article
  8. Biomimetic Coatings in Implant Dentistry: A Quick Update.Journal of functional biomaterials · 2023
    Review
  9. The effect of green synthesis of TiOVeterinary medicine and science · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. [Research Progress in Biomimetic Synthesis of Nano-Hydroxyapatite in Bone Tissue Engineering].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chih-Hsiang FangInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd, Taipei 10617, Taiwan.
Yi-Wen LinInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd, Taipei 10617, Taiwan.
Feng-Huei LinInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd, Taipei 10617, Taiwan.
Jui-Sheng SunDepartment of Orthopedic Surgery, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 10002, Taiwan.
Yuan-Hung ChaoSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, No. 1, Sec. 1, Ren-Ai Rd, Taipei 10051, Taiwan.
Hung-Ying LinSchool of Dentistry, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 10048, Taiwan.
Zwei-Chieng ChangSchool of Dentistry, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 10048, Taiwan.
National Taiwan University · TWNational Health Research Institutes · TW

Funding

Ministry of Science and Technology, Taipei, Taiwan, ROC [105-2314-B-002 -195 -MY3] and the National Taiwan University Hospital, Taipei, Taiwan, ROC [UN108-002]. Ministry of Science and Technology, Taipei, Taiwan, ROC [105-2314-B-002 -195 -MY3] and the National Taiwan University Hospital, Taipei, Taiwan, ROC [UN108-002].
6 · The paper itself

Abstract

The development of a novel alloplastic graft with both osteoinductive and osteoconductive properties is still necessary. In this study, we tried to synthesize a biomimetic hydroxyapatite microspheres (gelatin/nano-hydroxyapatite microsphere embedded with stromal cell-derived factor-1: GHM-S) from nanocrystalline hydroxyapatites and to investigate their therapeutic potential and effects on bone regeneration. In this study, hydroxyapatite was synthesized by co-precipitation of calcium hydroxide and orthophosphoric acid to gelatin solution. The microbial transglutaminase was used as the agent to crosslink the microspheres. The morphology, characterization, and thermal gravimetric analysis of microspheres were performed. SDF-1 release profile and in vitro biocompatibility and relative osteogenic gene expression were analyzed, followed by in vivo micro-computed tomography study and histological analysis. The synthesized hydroxyapatite was found to be similar to hydroxyapatite of natural bone tissue. The stromal cell-derived factor-1 was embedded into gelatin/hydroxyapatite microsphere to form the biomimetic hydroxyapatite microsphere. The stromal cell-derived factor-1 protein could be released in a controlled manner from the biomimetic hydroxyapatite microsphere and form a concentration gradient in the culture environment to attract the migration of stem cells. Gene expression and protein expression indicated that stem cells could differentiate or develop into pre-osteoblasts. The effect of bone formation by the biomimetic hydroxyapatite microsphere was assessed by an in vivo rats' alveolar bone defects model and confirmed by micro-CT imaging and histological examination. Our findings demonstrated that the biomimetic hydroxyapatite microsphere can enhance the alveolar bone regeneration. This design has potential be applied to other bone defects.

Indexed as

AnimalsBiomimetic MaterialsBone RegenerationCells, CulturedChemokine CXCL12DurapatiteGelatinHumansMicrospheresNanocompositesRatsChemokine CXCL12CXCL12 protein, humanDurapatiteGelatinalveolar bone defectbiomimeticgelatinmicrospherenano-hydroxyapatitestromal cell-derived factor-1

Identifiers

PMID31795225
PMCPMC6928996
OpenAlexW2989904056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.