Evidence map›Paper›PMID 31795157›Full record

ArticleVaccines2019

Measles Virus Infection and Immunity in a Suboptimal Vaccination Coverage Setting.

Monia Pacenti, Nataskya Maione, Enrico Lavezzo, Elisa Franchin, Federico Dal Bello, Lorena Gottardello, Luisa Barzon

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The Effects of Vaccination Status and Age on Clinical Characteristics and Severity of Measles Cases in the United States in the Postelimination Era, 2001-2022.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Monia PacentiMicrobiology and Virology Unit, Padova University Hospital, 35128 Padova, Italy.
Nataskya MaioneDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.
Enrico LavezzoDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.ORCID 0000-0002-3902-8356
Elisa FranchinMicrobiology and Virology Unit, Padova University Hospital, 35128 Padova, Italy.
Federico Dal BelloMicrobiology and Virology Unit, Padova University Hospital, 35128 Padova, Italy.
Lorena GottardelloDepartment of Hygiene and Public Health, Azienda ULSS 6 Euganea, 35131 Padova, Italy.
Luisa BarzonMicrobiology and Virology Unit, Padova University Hospital, 35128 Padova, Italy.ORCID 0000-0003-0720-8456
University of Padua · ITAULSS 2 Marca Trevigiana · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite efforts to improve surveillance and vaccination coverage, measles virus (MeV) continues to cause outbreaks also in high-income countries. As the reference laboratory of the Veneto Region, Italy, we analyzed changes in population immunity, described measles outbreaks, investigated MeV genetic diversity, and evaluated cross-protection of measles vaccination against MeV epidemic strains. Like most European areas, the Veneto Region has suboptimal measles vaccination coverage and is facing a growing public mistrust of vaccination. A progressive decline of measles vaccine uptake was observed during the last decade in the Veneto Region, leading to immunity gaps in children and young adults. Measles outbreaks were caused by the same MeV genotype B3, D4, and D8 strains that were circulating in other European countries. Eleven cases of measles were observed in immunized subjects. These cases were not associated with particular MeV genotypes nor with mutations in epitopes recognized by neutralizing antibodies. Accordingly, sera from fully vaccinated subjects cross-neutralized epidemic MeV strains, including the genotypes B3, D4, and D8, with the same high efficiency demonstrated against the vaccine strain. In fully vaccinated subjects, high MeV IgG antibody titers persisted up to 30 years following vaccination. These results support the use of the current measles-containing vaccines and strategies to strengthen vaccination.

Indexed as

cross-protectionepidemiologyimmunitymeaslesneutralizing antibodyoutbreaksecondary vaccine failurevaccine hesitancyvaccine uptakewhole-genome sequencing

Identifiers

PMID31795157
PMCPMC6963570
OpenAlexW2990721529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.