Evidence map›Paper›PMID 31795148›Full record

ArticleMarine drugs2019

Marine Bacteria from Rocas Atoll as a Rich Source of Pharmacologically Active Compounds.

Karen Y Velasco-Alzate, Anelize Bauermeister, Marcelo M P Tangerina, Tito M C Lotufo, Marcelo J P Ferreira, Paula C Jimenez, Gabriel Padilla, Norberto P Lopes, Letícia V Costa-Lotufo

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  3. Decontamination of DNA sequences from a Streptomyces genome for optimal genome mining.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Karen Y Velasco-AlzateDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo/SP, Brazil.
Anelize BauermeisterDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo/SP, Brazil.
Marcelo M P TangerinaDepartamento do Botânica, Instituto de Biociências, Universidade de São Paulo, 05508-090 São Paulo/SP, Brazil.
Tito M C LotufoDepartamento de Oceanografia Biológica, Instituto Oceanográfico, Universidade de São Paulo, 05508-120 São Paulo/SP, Brazil.
Marcelo J P FerreiraDepartamento do Botânica, Instituto de Biociências, Universidade de São Paulo, 05508-090 São Paulo/SP, Brazil.
Paula C JimenezDepartamento de Ciências do Mar, Universidade Federal de São Paulo, 11015-020 Santos/SP, Brazil.
Gabriel PadillaDepartamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo/SP, Brazil.
Norberto P LopesNPPNS, Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto/SP, Brazil.
Letícia V Costa-LotufoDepartamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo/SP, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/17177-6
6 · The paper itself

Abstract

Rocas Atoll is a unique environment in the equatorial Atlantic Ocean, hosting a large number of endemic species, however, studies on the chemical diversity emerging from this biota are rather scarce. Therefore, the present work aims to assess the metabolomic diversity and pharmacological potential of the microbiota from Rocas Atoll. A total of 76 bacteria were isolated and cultured in liquid culture media to obtain crude extracts. About one third (34%) of these extracts were recognized as cytotoxic against human colon adenocarcinoma HCT-116 cell line. 16S rRNA gene sequencing analyses revealed that the bacteria producing cytotoxic extracts were mainly from the Actinobacteria phylum, including

Indexed as

ActinobacteriaAtlantic OceanBiological ProductsHCT116 CellsHumansMolecular StructurePhylogenyStreptomycesBiological Productsmarine bacteriametabolomicsmicrobial diversitymolecular networksecondary metabolites

Identifiers

PMID31795148
PMCPMC6949966
OpenAlexW2991329666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.