Evidence map›Paper›PMID 31795126›Full record

ArticleMarine drugs2019

Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors.

Leanna A Marquart, Matthew W Turner, Lisa R Warner, Matthew D King, James R Groome, Owen M McDougal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Leanna A MarquartDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.
Matthew W TurnerBiomolecular Sciences PhD Program, Boise State University, Boise, ID 83725, USA.
Lisa R WarnerDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.
Matthew D KingDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.
James R GroomeDepartment of Biological Sciences, Idaho State University, Pocatello, ID 83209, USA.
Owen M McDougalDepartment of Chemistry and Biochemistry, Boise State University, Boise, ID 83725, USA.
Boise State University · USIdaho State University · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OCHOA-REPARAZ, JAVIER · 2014 to 2023
$22.7M
National Science Foundation 0619793National Science Foundation 0639251National Science Foundation 0923535NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095NIH HHS ISU sub-award SI3394-SB-825965NIH HHS P20GM103408NIH HHS P20GM109095
6 · The paper itself

Abstract

KTM is a 16 amino acid peptide with the sequence WCCSYPGCYWSSSKWC. Here, we present the nuclear magnetic resonance (NMR) structure and bioactivity of this rationally designed α-conotoxin (α-CTx) that demonstrates potent inhibition of rat α3β2-nicotinic acetylcholine receptors (rα3β2-nAChRs). Two bioassays were used to test the efficacy of KTM. First, a qualitative PC12 cell-based assay confirmed that KTM acts as a nAChR antagonist. Second, bioactivity evaluation by two-electrode voltage clamp electrophysiology was used to measure the inhibition of rα3β2-nAChRs by KTM (IC

Indexed as

AcetylcholineAmino Acid SequenceAnimalsConotoxinsNicotinic AntagonistsPC12 CellsPeptidesProtein BindingProtein IsoformsRatsReceptors, NicotinicAcetylcholinealpha-conotoxin MIIConotoxinsNicotinic Antagonistsnicotinic receptor alpha3beta2PeptidesProtein IsoformsReceptors, NicotinicDockoMaticnicotinic acetylcholine receptorNMRPC12 celltwo-electrode voltage clamp electrophysiologyα-conotoxin

Identifiers

PMID31795126
PMCPMC6950571
OpenAlexW2990930760

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.