ArticleNeuroImage. Clinical2019
White matter tracing combined with electric field simulation - A patient-specific approach for deep brain stimulation.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Active contact proximity to the cerebellothalamic tract predicts initial therapeutic current requirement with DBS for ET: an application of 7T MRI.Frontiers in neurology · 2023Article
- Advances in DBS Technology and Novel Applications: Focus on Movement Disorders.Current neurology and neuroscience reports · 2022Review
- Surgical Strategy for Directional Deep Brain Stimulation.Neurologia medico-chirurgica · 2022Article
- Deep Brain Stimulation: Emerging Tools for Simulation, Data Analysis, and Visualization.Frontiers in neuroscience · 2022Review
- Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson's Disease.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Optical Measurements during Asleep Deep Brain Stimulation Surgery along Vim-Zi Trajectories.Stereotactic and functional neurosurgery · 2020Article
- Article
- Lateral cerebellothalamic tract activation underlies DBS therapy for Essential Tremor.Brain stimulationArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveDeep brain stimulation (DBS) in zona incerta (Zi) is used for symptom alleviation in essential tremor (ET). Zi is positioned along the dentato-rubro-thalamic tract (DRT). Electric field simulations with the finite element method (FEM) can be used for estimation of a volume where the stimulation affects the tissue by applying a fixed isolevel (V
methodPatients with ET were implanted in Zi (lead 3389, n = 3, voltage mode; directional lead 6172, n = 1, current mode). Probabilistic reconstruction from diffusion MRI (dMRI) of the DRT (n = 8) was computed with FSL Toolbox. Brain tissue models were created for each patient (two homogenous, one heterogenous isotropic, one heterogenous anisotropic) and the respective V
resultCombined patient-specific tractography and electric field simulation was designed and evaluated, and all patients showed benefit from DBS. All V
conclusionA workflow for patient-specific electric field simulations in combination with reconstruction of DRT was successfully implemented. Accurate tissue classification is essential for electric field simulations, especially when using the current control stimulation. With an accurate targeting and tractography reconstruction, directional leads have the potential to tailor the electric field into the desired region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.