Evidence map›Paper›PMID 31795053›Full record

ArticleNeuroImage. Clinical2019

Abnormal dynamic properties of functional connectivity in disorders of consciousness.

Bolin Cao, Yan Chen, Ronghao Yu, Lixiang Chen, Ping Chen, Yihe Weng, Qinyuan Chen, Jie Song, Qiuyou Xie, Ruiwang Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 59 citations in OpenAlex.

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  12. Neuroimaging in Disorders of Consciousness and Recovery.Physical medicine and rehabilitation clinics of North America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bolin CaoCenter for the Study of Applied Psychology and MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, China.
Yan ChenCentre for Hyperbaric Oxygen and Neurorehabilitation, Liuhuaqiao Hospital, Guangzhou 510010, China.
Ronghao YuCentre for Hyperbaric Oxygen and Neurorehabilitation, Liuhuaqiao Hospital, Guangzhou 510010, China.
Lixiang ChenCenter for the Study of Applied Psychology and MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, China.
Ping ChenCenter for the Study of Applied Psychology and MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, China.
Yihe WengCenter for the Study of Applied Psychology and MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, China.
Qinyuan ChenCenter for the Study of Applied Psychology and MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, China.
Jie SongCenter for the Study of Applied Psychology and MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, China.
Qiuyou XieDepartment of Rehabilitation Medicine, ZhuJiang Hospital of Southern Medical University, Guangzhou 510280, China. Electronic address: xqy7180@163.com.
Ruiwang HuangCenter for the Study of Applied Psychology and MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, China. Electronic address: ruiwang.huang@gmail.com.
South China Normal University · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to research abnormal functional connectivity (FC) in patients with disorders of consciousness (DOC). However, most studies assumed steady spatial-temporal signal interactions between distinct brain regions during the scan period. The aim of this study was to explore abnormal dynamic functional connectivity (dFC) in DOC patients. After excluding 26 patients' data that failed to meet the requirements of imaging quality, we retained 19 DOC patients (12 with unresponsive wakefulness syndrome and 7 in a minimally conscious state, diagnosed with the Coma Recovery Scale-Revised [CRS-R]) for the dFC analysis. We used the sliding windows approach to construct dFC matrices. Then these matrices were clustered into distinct states using the k-means clustering algorithm. We found that the DOC patients showed decreased dFC in the sensory and somatomotor networks compared with the healthy controls. There were also significant differences in temporal properties, the mean dwell time (MDT) and the number of transitions (NT), between the DOC patients and the healthy controls. In addition, we also used a hidden Markov model (HMM) to test the robustness of the results. With the connectome-based predictive modeling (CPM) approach, we found that the properties of abnormal dynamic network can be used to predict the CRS-R scores of the patients after severe brain injury. These findings may contribute to a better understanding of the abnormal brain networks in DOC patients.

Indexed as

ConnectomeAdolescentAdultBrainBrain Injuries, TraumaticConsciousness DisordersFemaleFunctional NeuroimagingHumansHypoxia-Ischemia, BrainMagnetic Resonance ImagingMaleMarkov ChainsMiddle AgedNeural PathwaysPersistent Vegetative StateConnectome-based predictive model (CPM)Hidden Markov model (HMM)Independent component analysis (ICA)Sliding windows approach

Identifiers

PMID31795053
PMCPMC6881656
OpenAlexW2988255844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.