SynthesisNeuroImage. Clinical2019
Neural correlates of altered insight in frontotemporal dementia: a systematic review.
Synthesis in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Rapid Review of Interventions Designed to Enhance Personalised Care for People With Dementia When There Are Concerns About Reduced Awareness of Difficulties.International journal of geriatric psychiatry · 2025Pooled it
- Towards an integrative neuroscience of metacognition.Nature reviews. Neuroscience · 2026Review
- FUS Mislocalization Rewires a Cortical Gene Network to Drive Cognitive and Behavioral Impairment in ALS.medRxiv : the preprint server for health sciences · 2025Article
- The association between anosognosia and neuropsychiatric symptoms in neurodegenerative dementias: a narrative review.Frontiers in neurology · 2025Review
- When visual metacognition fails: widespread anosognosia for visual deficits.Trends in cognitive sciences · 2024Review
- Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly.Alzheimer's research & therapy · 2024Article
- Discrepancies in Patient and Caregiver Ratings of Personality Change in Alzheimer's Disease and Related Dementias.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Genetic overlap between cortical brain morphometry and frontotemporal dementia risk.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Metacognition, cortical thickness, and tauopathy in aging.Neurobiology of aging · 2022Article
- What Are the Neural Correlates of Impaired Awareness of Social Cognition and Function in Dementia? A Systematic Review.Brain sciences · 2022Review
- Associations between Cortical Thickness and Metamemory in Alzheimer's Disease.Brain imaging and behavior · 2022Article
- Anosognosia in Dementia: Evaluation of Perfusion Correlates Using 99mTc-HMPAO SPECT and Automated Brodmann Areas Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Detecting Biomarkers of Alzheimer's Disease Based on Multi-constrained Uncertainty-Aware Adaptive Sparse Multi-view Canonical Correlation Analysis.Journal of molecular neuroscience : MN · 2022Article
- Review
- Does awareness of condition help people with mild-to-moderate dementia to live well? Findings from the IDEAL programme.BMC geriatrics · 2021Article
- In vivo exploration of synaptic projections in frontotemporal dementia.Scientific reports · 2021Article
- The Association Between Maladaptive Metacognitive Beliefs and Emotional Distress in People Living With Amyotrophic Lateral Sclerosis.Frontiers in psychology · 2021Article
- Apathy, Executive Function, and Emotion Recognition Are the Main Drivers of Functional Impairment in Behavioral Variant of Frontotemporal Dementia.Frontiers in neurology · 2021Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Altered insight into disease or specific symptoms is a prominent clinical feature of frontotemporal dementia (FTD). Understanding the neural bases of insight is crucial to help improve FTD diagnosis, classification and management. A systematic review to explore the neural correlates of altered insight in FTD and associated syndromes was conducted. Insight was fractionated to examine whether altered insight into different neuropsychological/behavioural objects is underpinned by different or compatible neural correlates. 6 databases (Medline, Embase, PsycINFO, Web of Science, BIOSIS and ProQuest Dissertations & Theses Global) were interrogated between 1980 and August 2019. 15 relevant papers were found out of 660 titles screened. The studies included suggest that different objects of altered insight are associated with distinctive brain areas in FTD. For example, disease unawareness appears to predominantly correlate with right frontal involvement. In contrast, altered insight into social cognition potentially involves, in addition to frontal areas, the temporal gyrus, insula, parahippocampus and amygdala. Impaired insight into memory problems appears to be related to the frontal lobes, postcentral gyrus, parietal cortex and posterior cingulate. These results reflect to a certain extent those observed in other neurodegenerative conditions like Alzheimer's disease (AD) and also other brain disorders. Nevertheless, they should be cautiously interpreted due to variability in the methodological aspects used to reach those conclusions. Future work should triangulate different insight assessment approaches and brain imaging techniques to increase the understanding of this highly relevant clinical phenomenon in dementia.
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Registered trials
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