ArticleNeuroImage. Clinical2019
Disrupted functional and structural connectivity within default mode network contribute to WMH-related cognitive impairment.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multimodal voxel-wise of structural and functional brain alterations across the cerebral small vessel disease spectrum.Neuroradiology · 2026Pooled it
- Cognition and Health-Related Quality of Life After aSAH: The Role of Objective and Subjective Impairment.Neurology international · 2026Article
- Altered dynamic functional connectivity associated with cognition in diverse severity of white matter hyperintensity.BMC medical imaging · 2025Article
- Longitudinal tractography of the mouse corpus callosum reveals topographical order and differences due to sex and aging.Brain structure & function · 2025Article
- Impact of glucose fluctuations on white matter hyperintensity in type 2 diabetic patients.Acta diabetologica · 2025Article
- Brain functional and structural alteration following acute carbon monoxide poisoning contribute to delayed neurological sequelae.Scientific reports · 2025Article
- A window into the brain: multimodal MRI assessment of vascular cognitive impairment.Frontiers in neuroscience · 2025Review
- A comparative study of risk factors in predictive models for cognitive dysfunction in patients with leukoaraiosis based on machine learning algorithms.Frontiers in neuroscience · 2025Article
- Connectome gradient dysfunction contributes to white matter hyperintensity-related cognitive decline.CNS neuroscience & therapeutics · 2024Article
- Article
- Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease.Brain and behavior · 2024Article
- White matter hyperintensities influence distal cortical β-amyloid accumulation in default mode network pathways.Brain and behavior · 2023Article
- Higher Functional Connectivity of Ventral Attention and Visual Network to Maintain Cognitive Performance in White Matter Hyperintensity.Aging and disease · 2023Article
- A functional connectome signature of blood pressure in >30 000 participants from the UK biobank.Cardiovascular research · 2023Article
- Subsystem mechanisms of default mode network underlying white matter hyperintensity-related cognitive impairment.Human brain mapping · 2023Article
- Optogenetic Stimulation of mPFC Alleviates White Matter Injury-Related Cognitive Decline after Chronic Ischemia through Adaptive Myelination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients.BMC neurology · 2023Article
- Brain effective connectivity and functional connectivity as markers of lifespan vascular exposures in middle-aged adults: The Bogalusa Heart Study.Frontiers in aging neuroscience · 2023Article
- Superficial white matter microstructure affects processing speed in cerebral small vessel disease.Human brain mapping · 2022Article
- Brain Metabolic Network Redistribution in Patients with White Matter Hyperintensities on MRI Analyzed with an Individualized Index Derived fromKorean journal of radiology · 2022Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe prevalence of white matter hyperintensities (WMH) rises dramatically with aging. Both the progression of WMH and changing patterns of default mode network (DMN) have been proven to be closely associated with cognitive function. The present study hypothesized that changes in functional connectivity and structural connectivity of DMN contributed to WMH related cognitive impairment.
methodsA total of 116 subjects were enrolled from the Cerebral Small Vessel Disease Register in Drum Tower Hospital of Nanjing University, and were distributed across three categories according to Fazekas rating scale: WMH I (n = 57), WMH II (n = 34), and WMH III(n = 25). All participants underwent neuropsychological tests and multimodal MRI scans, including diffusion tensor imaging and resting-state fMRI imaging. The alterations of functional connectivity and structural connectivity within the DMN were further explored.
resultsAge and hypertension were risk factors for WMH progression. Subjects with a higher WMH burden displayed higher DMN functional connectivity in the medial frontal gyrus, while lower DMN functional connectivity in the thalamus. After adjusting for aging, gender, and education, the increased DMN functional connectivity in the medial frontal gyrus, and the increased mean diffusivity of the white matter tracts between the hippocampus and posterior cingulate cortex were independent indicators of worse performance in memory. Moreover, the decreased DMN functional connectivity in the thalamus and increased mean diffusivity of the white matter tracts between the thalamus and posterior cingulate cortex were independent risk factors for a slower processing speed.
conclusionThe changes in functional connectivity and structural connectivity within the DMN attributed to WMH progression were responsible for the development of cognitive impairment.
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