ArticleNeuroImage. Clinical2019
MR diffusion changes in the perimeter of the lateral ventricles demonstrate periventricular injury in post-hemorrhagic hydrocephalus of prematurity.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Asymptomatic ventriculomegaly in myelomeningocele: a matched cohort study of neuropsychological outcomes across institutions with varying shunt rates.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Neuroinflammatory pathways and potential therapeutic targets in neonatal post-hemorrhagic hydrocephalus.Pediatric research · 2025Review
- Prediction of post-hemorrhagic ventricular dilatation trajectory using a growth mixture model in preterm infants.Pediatric research · 2025Article
- Ventricular catheter tissue obstruction and shunt malfunction in 9 hydrocephalus etiologies.Journal of neurosurgery. Pediatrics · 2024Article
- Structural and functional connectivity in hydrocephalus: a scoping review.Neurosurgical review · 2024Article
- Spontaneous resolution of post-hemorrhagic ventricular dilatation in preterm newborns and neurodevelopment.Pediatric research · 2023Article
- Neuroimaging of structural and functional connectivity in preterm infants with intraventricular hemorrhage.Seminars in perinatology · 2022Review
- Automatic brain segmentation in preterm infants with post-hemorrhagic hydrocephalus using 3D Bayesian U-Net.Human brain mapping · 2022Article
- Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter.Fluids and barriers of the CNS · 2022Article
- Microstructural Periventricular White Matter Injury in Post-hemorrhagic Ventricular Dilatation.Neurology · 2022Article
- Biochemical profile of human infant cerebrospinal fluid in intraventricular hemorrhage and post-hemorrhagic hydrocephalus of prematurity.Fluids and barriers of the CNS · 2021Article
- The impact of hypoxia on blood-brain, blood-CSF, and CSF-brain barriers.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Post-hemorrhagic ventricular dilatation: inter-observer reliability of ventricular size measurements in extremely preterm infants.Pediatric research · 2021Observational
- Management of Post-hemorrhagic Ventricular Dilatation in the Infant Born Preterm.The Journal of pediatrics · 2020Article
- This was the year that was: brain barriers and brain fluid research in 2019.Fluids and barriers of the CNS · 2020Article
- Semi-automated segmentation of the lateral periventricular regions using diffusion magnetic resonance imaging.MethodsX · 2020Article
- Leptomeningeal disease and tumor dissemination in a murine diffuse intrinsic pontine glioma model: implications for the study of the tumor-cerebrospinal fluid-ependymal microenvironment.Neuro-oncology advancesArticle
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesInjury to the preterm lateral ventricular perimeter (LVP), which contains the neural stem cells responsible for brain development, may contribute to the neurological sequelae of intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus of prematurity (PHH). This study utilizes diffusion MRI (dMRI) to characterize the microstructural effects of IVH/PHH on the LVP and segmented frontal-occipital horn perimeters (FOHP). STUDY
designProspective study of 56 full-term infants, 72 very preterm infants without brain injury (VPT), 17 VPT infants with high-grade IVH without hydrocephalus (HG-IVH), and 13 VPT infants with PHH who underwent dMRI at term equivalent. LVP and FOHP dMRI measures and ventricular size-dMRI correlations were assessed.
resultsIn the LVP, PHH had consistently lower FA and higher MD and RD than FT and VPT (p<.050). However, while PHH FA was lower, and PHH RD was higher than their respective HG-IVH measures (p<.050), the MD and AD values did not differ. In the FOHP, PHH infants had lower FA and higher RD than FT and VPT (p<.010), and a lower FA than the HG-IVH group (p<.001). While the magnitude of AD in both the LVP and FOHP were consistently less in the PHH group on pairwise comparisons to the other groups, the differences were not significant (p>.050). Ventricular size correlated negatively with FA, and positively with MD and RD (p<.001) in both the LVP and FOHP. In the PHH group, FA was lower in the FOHP than in the LVP, which was contrary to the observed findings in the healthy infants (p<.001). Nevertheless, there were no regional differences in AD, MD, and RD in the PHH group.
conclusionHG-IVH and PHH results in aberrant LVP/FOHP microstructure, with prominent abnormalities among the PHH group, most notably in the FOHP. Larger ventricular size was associated with greater magnitude of abnormality. LVP/FOHP dMRI measures may provide valuable biomarkers for future studies directed at improving the management and neurological outcomes of IVH/PHH.
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