Trial reportNeuroImage. Clinical2019
Stability of frontal alpha asymmetry in depressed patients during antidepressant treatment.
Trial report in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Resting and TMS-EEG markers of treatment response in major depressive disorder: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Subtyping depression using brain-gastric electrophysiology for early prediction of antidepressant response: a multicentric clinical study.Frontiers in psychiatry · 2026Trial
- Molecular, Structural, and Functional Neuroimaging in Major Depression.Advances in experimental medicine and biology · 2026Review
- Neurofeedback in Major Depression.Advances in experimental medicine and biology · 2026Review
- Review
- Associations of physical activity, sedentary time, sleep quality, and resting EEG with mild depressive symptoms in college students: a cross-sectional study.BMC public health · 2025Article
- Predicting Depression Therapy Outcomes Using EEG-Derived Amplitude Polar Maps.Brain sciences · 2025Article
- Correlations between depressive symptoms, verbal working memory, and physical activity in university students: evidence based on resting EEG.BMC psychiatry · 2025Article
- Concurrent and prospective relations between aberrant stress-induced frontal alpha asymmetry and cannabis use disorder.Addiction neuroscience · 2025Article
- Article
- Meta analysis of resting frontal alpha asymmetry as a biomarker of depression.Npj mental health research · 2025Article
- Quantitative and qualitative electroencephalography in the diagnosis and monitoring of depression. A modern approach to clinical neurophysiology.Frontiers in human neuroscience · 2025Review
- Resting-State EEG Alterations of Practice-Related Spectral Activity and Connectivity Patterns in Depression.Biomedicines · 2024Article
- Frontal Alpha Asymmetry and Its Modulation by Monoaminergic Neurotransmitters in Depression.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Review
- Accelerated TMS - moving quickly into the future of depression treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Closed-loop neurostimulation for the treatment of psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Functional role of frontal electroencephalogram alpha asymmetry in the resting state in patients with depression: A review.World journal of clinical cases · 2023Review
- Resting-state frontal, frontlateral, and parietal alpha asymmetry:A pilot study examining relations with depressive disorder type and severity.Frontiers in psychology · 2023Article
- A review of critical brain oscillations in depression and the efficacy of transcranial magnetic stimulation treatment.Frontiers in psychiatry · 2023Review
- Sensory Processing and Autistic Traits: Mediation Effect of Frontal Alpha Asymmetry.Occupational therapy international · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFrontal alpha asymmetry (FAA) is a proposed prognostic biomarker in major depressive disorder (MDD), conventionally acquired with electroencephalography (EEG). Although small studies attributed trait-like properties to FAA, a larger sample is needed to reliably asses this characteristic. Furthermore, to use FAA to predict treatment response, determining its stability, including the potential dependency on depressive state or medication, is essential.
methodsIn the international Study to Predict Optimized Treatment in Depression (iSPOT-D), a multi-center, randomized, prospective open-label trial, 1008 MDD participants were randomized to treatment with escitalopram, sertraline or venlafaxine-extended release. Treatment response was established eight weeks after treatment initiation and resting state EEG was measured both at baseline and after eight weeks (n = 453).
resultsFAA did not change significantly after eight weeks of treatment (n = 453, p = .234), nor did we find associations with age, sex, depression severity, or change in depression severity. After randomizing females to escitalopram or sertraline, for whom treatment response could be predicted in an earlier study, FAA after eight weeks resulted in equivalent response prediction as baseline FAA (one tailed p = .028).
conclusionWe demonstrate that FAA is a stable trait, robust to time, state and pharmacological status. This confirms FAA stability. Furthermore, as prediction of treatment response is irrespective of moment of measurement and use of medication, FAA can be used as a state-invariant prognostic biomarker with promise to optimize MDD treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.