Evidence map›Paper›PMID 31794958›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020

Effects of ventral intermediate nucleus deep brain stimulation across multiple effectors in essential tremor.

B J Wilkes, A Wagle Shukla, A Casamento-Moran, C W Hess, E A Christou, M S Okun, D E Vaillancourt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

B J WilkesDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
A Wagle ShuklaDepartment of Neurology, Fixel Institute for Neurological Diseases, Movement Disorders and Neurorestoration Program, University of Florida, Gainesville, FL, USA.
A Casamento-MoranDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
C W HessDepartment of Neurology, Fixel Institute for Neurological Diseases, Movement Disorders and Neurorestoration Program, University of Florida, Gainesville, FL, USA.
E A ChristouDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
M S OkunDepartment of Neurology, Fixel Institute for Neurological Diseases, Movement Disorders and Neurorestoration Program, University of Florida, Gainesville, FL, USA.
D E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Neurology, Fixel Institute for Neurological Diseases, Movement Disorders and Neurorestoration Program, University of Florida, Gainesville, FL, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. Electronic address: vcourt@ufl.edu.
University of Florida · US

Funding

Role of the Cortex and Cerebellum in Visually-Guided Motor BehaviorR01NS058487 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAFFEE, MICHAEL S., VAILLANCOURT, DAVID E · 2008 to 2025
$6.1M
Functional Brain Networks in Essential Tremor and Dystonic TremorK23NS092957 · NINDS · UNIVERSITY OF FLORIDA · PI WAGLE SHUKLA, APARNA · 2016 to 2019
$703k
NINDS NIH HHS K23 NS092957NINDS NIH HHS R01 NS058487
6 · The paper itself

Abstract

objectiveEssential tremor (ET) prominently affects the upper-limbs during voluntary movements, but can also affect the lower-limbs, head, and chin. Although deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) of thalamus improves both clinical ratings and quantitative measures of tremor, no study has quantified effects of DBS on tremor across multiple body parts. Our objective was to quantify therapeutic effects of DBS across multiple body parts in ET.

methodsWe performed quantitative assessment of tremor in ET patients who had DBS for at least one year. We assessed tremor on and off VIM-stimulation using triaxial accelerometers on the upper-limbs, lower-limbs, head and chin during seated and standing tasks.

resultsVIM-DBS significantly reduced tremor, but there was no statistical difference in degree of tremor reduction across the measured effectors. Compared to healthy controls, ET patients treated with DBS showed significantly greater tremor power (4-8 Hz) across all effectors during seated and standing tasks.

conclusionsVIM-DBS reduced tremor in ET patients. There was no significant difference in the degree of tremor reduction across the measured effectors. SIGNIFICANCE: This study provides new quantitative evidence that VIM-DBS is effective at reducing tremor across multiple parts of the body.

Indexed as

AccelerationAccelerometryAgedAged, 80 and overCase-Control StudiesChinDeep Brain StimulationEssential TremorFemaleHandHeadHumansLegMaleMiddle AgedSitting PositionAccelerometerDeep brain stimulationEssential tremorThalamus

Identifiers

PMID31794958
PMCPMC6920570
OpenAlexW2990909301

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.