ArticleNeuroImage. Clinical2020
Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress.Molecular psychiatry · 2022Pooled it
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Effects of Alpha Transcranial Alternating Current Stimulation on Stress Reactivity and Decision Making: A Randomized Sham-Controlled Trial.Biological psychiatry global open science · 2026Article
- A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder.Journal of affective disorders reports · 2026Article
- Altered amygdala and striatal responsivity and prediction error encoding of temporal reward dynamics in post-trauma psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview.Frontiers in psychiatry · 2025Review
- Neurophysiological characteristics of reward processing in deaf college students under different social contexts.Frontiers in neuroscience · 2025Article
- Acute Angiotensin II Receptor Blockade Facilitates Parahippocampal Processing During Memory Encoding in High-Trait-Anxious Individuals.Biological psychiatry global open science · 2024Article
- Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach.Translational psychiatry · 2023Article
- Your smile won't affect me: Association between childhood maternal antipathy and adult neural reward function in a transdiagnostic sample.Translational psychiatry · 2023Article
- The effects of trauma on feedback processing: an MEG study.Frontiers in neuroscience · 2023Article
- Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach.Translational psychiatry · 2022Article
- Childhood maltreatment and its role in the development of pain and psychopathology.The Lancet. Child & adolescent health · 2022Review
- Cross-sectional study of traumatic stress disorder in frontline nurses 6 mo after the outbreak of the COVID-19 in Wuhan.World journal of psychiatry · 2022Article
- Reward Processing and Circuit Dysregulation in Posttraumatic Stress Disorder.Frontiers in psychiatry · 2021Article
- The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli?Chronic stress (Thousand Oaks, Calif.)Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies suggest that Posttraumatic Stress Disorder (PTSD) might be associated with dysfunctional reward circuitry. However, further research is needed to understand the key role of the reward system in PTSD symptomatology.
methodsTwenty participants with PTSD and 21 Trauma-Exposed matched Controls (TECs) completed the Monetary Incentive Delay (MID) task during an MRI session. Reaction times (RTs) and hit rates were recorded. Brain activity was investigated during the anticipation and the outcome of monetary gains and losses.
resultsDuring the anticipation of monetary loss, PTSD participants had higher RTs than TECs. However, the groups did not differ at the neurofunctional level. During successful avoidance of monetary loss, PTSD patients showed higher activation than TECs in the left caudate nucleus. During the anticipation of monetary gains, no differences in RTs were found between groups. PTSD patients had specific activations in the right amygdala, nucleus accumbens, putamen, and middle frontal gyrus (p < 0.05 family-wise error (FWE)-corrected), while TECs had specific activation in the anterior cingulate cortex. When obtaining monetary gains, PTSD patients had specific activation in the caudate nucleus, while TECs had specific activations in the right hypothalamus, subthalamic nucleus, and left inferior frontal gyrus.
conclusionFor the first time, functional brain activation during both the anticipation and the outcome of monetary rewards is reported altered in PTSD patients. These alterations might be associated with the complex symptomatology of PTSD.
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