Evidence map›Paper›PMID 31794442›Full record

ArticlePsychosomatic medicine

Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample.

Carol Kan, Kaushalya Jayaweera, Anushka Adikari, Sisira Siribaddana, Helena M S Zavos, Lisa Harber-Aschan, Athula Sumathipala, Matthew Hotopf, Khalida Ismail, Frühling Rijsdijk

Open access · hybridAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Carol KanFrom the Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (Kan, Hotopf, Ismail), King's College London, London, United Kingdom; Institute for Research and Development (Jayaweera, Adikari, Sumathipala), Colombo; Department of Medicine, University of Rajarata (Siribaddana), Mihintale, Sri Lanka; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience (Zavos), King's College London, London, United Kingdom; Department of Public Health Sciences (Aschan), Karolinska Institutet, Solna, Sweden; Research Institute for Primary Care and Health Science (Sumathipala), Keele University, Newcastle, United Kingdom; and Social Genetic and Developmental Research Centre, Institute of Psychiatry, Psychology and Neuroscience (Rijsdijk), King's College London, London, United Kingdom.
Kaushalya Jayaweera
Anushka Adikari
Sisira Siribaddana
Helena M S Zavos
Lisa Harber-Aschan
Athula Sumathipala
Matthew Hotopf
Khalida Ismail
Frühling Rijsdijk
University of Colombo · LKKing's College London · GB

Funding

Department of HealthWellcome TrustWellcome Trust 093206/Z/10/Z
6 · The paper itself

Abstract

objectiveResults from twin studies examining the genetic overlap between type 2 diabetes and depression are currently inconclusive. This question has not been addressed in non-Western populations. We aimed to examine whether there are common genetic factors between type 2 diabetes and depression in a Sri Lankan population using genetic model-fitting analysis.

methodThe Colombo Twin and Singleton Study-Phase 2 consists of 2019 singletons, and 842 monozygotic and 578 dizygotic twin pairs. The primary outcomes were self-reported type 2 diabetes diagnosis and Beck Depression Inventory scores. Standard bivariate twin models were fitted to estimate the genetic and environmental (co)variance of type 2 diabetes and depression.

resultsIn the best-fitting model, the phenotypic correlation between type 2 diabetes and depression was significant in female individuals only (r = 0.15 [0.08-0.21]). This association was primarily attributed to a significant genetic correlation between the traits (rA = 0.53 [0.19-0.98]).

conclusionsIn female individuals, but not male individuals, we found a significant genetic overlap between type 2 diabetes and depression in the context of a modest phenotypic correlation.

Indexed as

AdultDepressionDiabetes Mellitus, Type 2Diseases in TwinsFemaleHumansMaleMiddle AgedPhenotypeSex FactorsSri LankaTwins, DizygoticTwins, Monozygotic

Identifiers

PMID31794442
PMCPMC7012333
OpenAlexW2992680071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.