Evidence map›Paper›PMID 31794265›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2020

Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor.

Sarah N Framnes-DeBoer, Ellen Bakke, Suma Yalamanchili, Hannah Peterson, Darleen A Sandoval, Randy J Seeley, Deanna M Arble

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. The beneficial metabolic actions of prolactin.Frontiers in endocrinology · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sarah N Framnes-DeBoerDepartment of Biological Sciences, Marquette University, Milwaukee, Wisconsin.ORCID 0000-0003-2424-4301
Ellen BakkeDepartment of Biological Sciences, Marquette University, Milwaukee, Wisconsin.
Suma YalamanchiliUniversity of Cincinnati Medical Center, Cincinnati, Ohio.
Hannah PetersonDepartment of Biological Sciences, Marquette University, Milwaukee, Wisconsin.
Darleen A SandovalDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
Randy J SeeleyDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
Deanna M ArbleDepartment of Biological Sciences, Marquette University, Milwaukee, Wisconsin.
Marquette University · USUniversity of Michigan · USUniversity of Cincinnati · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Dissecting mechanisms of GLP-1 based therapies for Type II DiabetesR01DK093848 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEELEY, RANDY J · 2012 to 2015
$1.5M
Circadian disruption and bariatric surgery: impact on metabolism, clock biologyF32DK097867 · NIDDK · UNIVERSITY OF CINCINNATI · PI ARBLE, DEANNA MARIE · 2012 to 2013
$100k
NIDDK NIH HHS F32 DK097867NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK093848
6 · The paper itself

Abstract

Bromocriptine, a dopamine D2 receptor agonist originally used for the treatment of hyperprolactinemia, is largely successful in reducing hyperglycemia and improving glucose tolerance in type 2 diabetics. However, the mechanism behind bromocriptine's effect on glucose intolerance is unclear. Here, we tested three hypotheses, that bromocriptine may exert its effects on glucose metabolism by

Indexed as

AnimalsBlood GlucoseBromocriptineCircadian RhythmCLOCK ProteinsDiet, High-FatDisease Models, AnimalDopamine AgonistsGlucose Tolerance TestInsulinMiceMice, KnockoutMutationObesityProlactinReceptor, Melanocortin, Type 4Blood GlucoseBromocriptineClock protein, mouseCLOCK ProteinsDopamine AgonistsInsulinMC4R protein, mouseProlactinReceptor, Melanocortin, Type 4bromocriptinecircadian disruptiondiabetesobesityprolactin

Identifiers

PMID31794265
PMCPMC6985791
OpenAlexW2992250194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.