ArticleAmerican journal of physiology. Endocrinology and metabolism2020
Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle.
Article in American journal of physiology. Endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- A systematic review and meta-analysis of the SIRT1 response to exercise.Scientific reports · 2023Pooled it
- Factors Influencing AMPK Activation During Cycling Exercise: A Pooled Analysis and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Performance effects of periodized carbohydrate restriction in endurance trained athletes - a systematic review and meta-analysis.Journal of the International Society of Sports Nutrition · 2021Pooled it
- Sprint-interval training with post-exercise blood flow restriction increases mitochondrial content and respiration.The Journal of physiology · 2026Article
- The efficacy and physiological bases of small muscle mass exercise in health and disease.Experimental physiology · 2026Review
- Training Session Models in Endurance Sports: A Norwegian Perspective on Best Practice Recommendations.Sports medicine (Auckland, N.Z.) · 2024Article
- Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023Review
- Advances in exercise to alleviate sarcopenia in older adults by improving mitochondrial dysfunction.Frontiers in physiology · 2023Review
- From juniors to seniors: changes in training characteristics and aerobic power in 17 world-class cross-country skiers.Frontiers in physiology · 2023Article
- New Horizons in Carbohydrate Research and Application for Endurance Athletes.Sports medicine (Auckland, N.Z.) · 2022Review
- The Impact of Training on the Loss of Cardiorespiratory Fitness in Aging Masters Endurance Athletes.International journal of environmental research and public health · 2022Review
- Protein signalling in response to ex vivo dynamic contractions is independent of training status in rat skeletal muscle.Experimental physiology · 2022Article
- The effect of endurance exercise and rosehip extract supplementation on the expression of P53 and cytochrome C genes in male rat heart.Journal of cardiovascular and thoracic research · 2022Article
- Article
- No Differences Between 12 Weeks of Block- vs. Traditional-Periodized Training in Performance Adaptations in Trained Cyclists.Frontiers in physiology · 2022Article
- The Effect of Sleep Restriction, With or Without Exercise, on Skeletal Muscle Transcriptomic Profiles in Healthy Young Males.Frontiers in endocrinology · 2022Article
- Under the Hood: Skeletal Muscle Determinants of Endurance Performance.Frontiers in sports and active living · 2021Review
- An Examination and Critique of Current Methods to Determine Exercise Intensity.Sports medicine (Auckland, N.Z.) · 2020Review
- The Molecular Adaptive Responses of Skeletal Muscle to High-Intensity Exercise/Training and Hypoxia.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise-induced increases in peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and p53 protein content in the nucleus mediate the initial phase of exercise-induced mitochondrial biogenesis. Here, we investigated whether exercise-induced increases in these and other markers of mitochondrial biogenesis were altered after 40 sessions of twice-daily high-volume, high-intensity interval training (HVT) in human skeletal muscle. Vastus lateralis muscle biopsies were collected from 10 healthy recreationally active participants before, immediately postexercise, and 3 h after a session of high-intensity interval exercise (HIIE) performed at the same absolute exercise intensity before and after HVT (pre-HVT and post-HVT, respectively). The protein content of common markers of exercise-induced mitochondrial biogenesis was assessed in nuclear- and cytosolic-enriched fractions by immunoblotting; mRNA contents of key transcription factors and mitochondrial genes were assessed by qPCR. Despite exercise-induced increases in PGC-1α, p53, and plant homeodomain finger-containing protein 20 (PHF20) protein content, the phosphorylation of p53 and acetyl-CoA carboxylase (p-p53 Ser
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.