ArticleNeuropsychopharmacology reports2020
Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures.
Article in Neuropsychopharmacology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Astrocytic Igfbp2 Promotes Spontaneous Seizures in a Mouse Model of Mesial Temporal Lobe Epilepsy.Glia · 2026Article
- Marked differences in the effects of levetiracetam and its analogue brivaracetam on microglial, astrocytic, and neuronal density in the rat model of kainic acid-induced temporal lobe epilepsy.Frontiers in pharmacology · 2025Article
- Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy.CNS neuroscience & therapeutics · 2023Article
- Article
- The Circadian Clock of Polarized Microglia and Its Interaction with Mouse Brain Oscillators.Cellular and molecular neurobiology · 2023Article
- Microglia play beneficial roles in multiple experimental seizure models.bioRxiv : the preprint server for biology · 2023Article
- Partial Depletion of Microglia Attenuates Long-Term Potentiation Deficits following Repeated Blast Traumatic Brain Injury in Organotypic Hippocampal Slice Cultures.Journal of neurotrauma · 2023Article
- Inflammation-related genes and immune infiltration landscape identified in kainite-induced temporal lobe epilepsy based on integrated bioinformatics analysis.Frontiers in neuroscience · 2022Article
- Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures.Frontiers in cellular neuroscience · 2022Article
- Reactive morphology of dividing microglia following kainic acid administration.Frontiers in neuroscience · 2022Article
- Article
- Pro- and anti-epileptic roles of microglia.Neural regeneration research · 2021Review
- Microglia provide structural resolution to injured dendrites after severe seizures.Cell reports · 2021Article
- Biocompatibility of Platinum Nanoparticles in BrainFrontiers in neuroscience · 2021Article
- Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures.Neuropsychopharmacology reports · 2020Article
- Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation.Frontiers in cellular neuroscience · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStatus epilepticus-induced hippocampal neuronal death, astrogliosis, and the activation of microglia are common pathological changes in mesial temporal lobe epilepsy (mTLE) with resistance to antiepileptic drugs. Neuronal death in mTLE gradually progresses and is involved in the aggravation of epilepsy and the impairment of hippocampus-dependent memory. Thus, clarifying the cellular mechanisms by which neurons are protected in mTLE will significantly contribute to the treatment of epilepsy. Here, mainly using hippocampal slice cultures with or without the pharmacological depletion of microglia, we directly examined whether microglia, the resident immune cells of the brain that can act either neurotoxically or in a neuroprotective manner, accelerate or attenuate kainic acid (KA)-induced neuronal death in vitro.
methodsHippocampal slice cultures were treated with KA to induce neuronal death in vitro. Clodronate-containing liposomes or PLX3397 was used to deplete microglia in hippocampal slice cultures, and the effect on KA-induced neuronal death was immunohistochemically assessed.
resultsThe loss of microglia significantly promoted a decrease in neuronal density in KA-treated hippocampal slice cultures.
conclusionOur results suggest that microglia are neuroprotective against KA-induced neuronal death in slice cultures.
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