SynthesisThe British journal of dermatology2020
What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review.
Synthesis in The British journal of dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Educational and psychological interventions for managing atopic dermatitis (eczema).The Cochrane database of systematic reviews · 2024Pooled it
- An Umbrella Review of Meta-Analyses Evaluating Associations between Human Health and Exposure to Major Classes of Plastic-Associated Chemicals.Annals of global health · 2024Pooled it
- Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index.Scientific reports · 2020Pooled it
- Early-Life Secondhand Smoke Exposure and Development of Atopic Dermatitis up to Adulthood.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Gene-environment interaction analysis in atopic eczema: evidence from large population datasets and modellingmedRxiv : the preprint server for health sciences · 2025Article
- Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.Allergy · 2025Article
- Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025Review
- Atopic dermatitis and tobacco smoke exposure during childhood and adolescence.The journal of allergy and clinical immunology. Global · 2025Article
- Genetic and Immunological Pathogenesis of Atopic Dermatitis.The Journal of investigative dermatology · 2024Review
- Epidemiology of adult patients with atopic dermatitis in AWARE 1: A second international survey.The World Allergy Organization journal · 2023Article
- Genetic Variants in Epidermal Differentiation Complex Genes as Predictive Biomarkers for Atopic Eczema, Allergic Sensitization, and Eczema-Associated Asthma in a 6-Year Follow-Up Case-Control Study in Children.Journal of clinical medicine · 2022Article
- Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis.Journal of asthma and allergy · 2022Review
- Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort.The British journal of dermatology · 2021Article
- Article
- The Role of Environmental Exposures in Atopic Dermatitis.Current allergy and asthma reports · 2020Review
- Expanding cancer predisposition genes with ultra-rare cancer-exclusive human variations.Scientific reports · 2020Article
- Prevalence of filaggrin gene polymorphisms (exon-3) in patients with atopic dermatitis in a multiracial Brazilian population.Anais brasileiros de dermatologiaArticle
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Authors and funding
17 authors at 11 institutions in 3 countries.
Funding
Abstract
backgroundEpidemiological studies indicate that gene-environment interactions play a role in atopic dermatitis (AD).
objectivesTo review the evidence for gene-environment interactions in AD aetiology, focusing on filaggrin (FLG) loss-of-function mutations.
methodsA systematic search from inception to September 2018 in Embase, MEDLINE and BIOSIS was performed. Search terms included all synonyms for AD and filaggrin/FLG; any genetic or epidemiological study design using any statistical methods were included. Quality assessment using criteria modified from guidance (ROBINS-I and Human Genome Epidemiology Network) for nonrandomized and genetic studies was completed, including consideration of power. Heterogeneity of study design and analyses precluded the use of meta-analysis.
resultsOf 1817 papers identified, 12 studies fulfilled the inclusion criteria required and performed formal interaction testing. There was some evidence for FLG-environment interactions in six of the studies (P-value for interaction ≤ 0·05), including early-life cat ownership, older siblings, water hardness, phthalate exposure, higher urinary phthalate metabolite levels (which all increased AD risk additional to FLG null genotype) and prolonged breastfeeding (which decreased AD risk in the context of FLG null genotype). Major limitations of published studies were the low numbers of individuals (ranging from five to 94) with AD and FLG loss-of-function mutations and exposure to specific environmental factors, and variation in exposure definitions.
conclusionsEvidence on FLG-environment interactions in AD aetiology is limited. However, many of the studies lacked large enough sample sizes to assess these interactions fully. Further research is needed with larger sample sizes and clearly defined exposure assessment. Linked Comment: Park and Seo. Br J Dermatol 2020; 183:411.
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