ArticleThe Journal of clinical investigation2020
Not all proteinuria is created equal.
Article in The Journal of clinical investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Decreasing Prevalence of Chronic Kidney Disease Among U.S. Adults With Diabetes, 1999-2018.AJPM focus · 2026Article
- Four missense genetic variants inFrontiers in endocrinology · 2023Article
- Predicting Progression of Kidney Injury Based on Elastography Ultrasound and Radiomics Signatures.Diagnostics (Basel, Switzerland) · 2022Article
- Novel pathogenic variants in CUBN uncouple proteinuria from renal function.Journal of translational medicine · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Albuminuria acts as a marker of progressive chronic kidney disease and as an indicator for initiation of hypertension treatment via modulation of the renin-angiotensin-aldosterone system with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors. However, the true significance of albuminuria has yet to be fully defined. Is it merely a marker of underlying pathophysiology, or does it play a causal role in the progression of kidney disease? The answer remains under debate. In this issue of the JCI, Bedin et al. used next-generation sequencing data to identify patients with chronic proteinuria who had biallelic variants in the cubilin gene (CUBN). Through investigation of these pathogenic mutations in CUBN, the authors have further illuminated the clinical implications of albuminuria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.