Evidence map›Paper›PMID 31793864›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2020

Diagnostic accuracy of prostate cancer antigen 3 (PCA3) prior to first prostate biopsy: A systematic review and meta-analysis.

Sandra Viviana Muñoz Rodríguez, Herney Andrés García-Perdomo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sandra Viviana Muñoz RodríguezUniversidad Libre, National Epidemiologist, Coomeva Prepaid Medicine, Cali, Colombia.
Herney Andrés García-PerdomoSchool of Medicine, Universidad del Valle, Cali, Colombia.
Universidad del Valle · COUniversidad Libre de Colombia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe aimed to determine the diagnostic accuracy of the prostate cancer antigen 3 (PCA3) test before performing the first biopsy compared with prostate biopsy for the diagnosis of prostate cancer (PCa).

methodsA systematic search was performed in MEDLINE, EMBASE, CENTRAL, LILACS, reference lists, specialized journals in urology and cancer, and unpublished literature. The population was adults with suspected PCa, and the intervention was the measurement of PCA3 in urine samples for the diagnosis of PCa. The quality of studies was evaluated with the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. The operative characteristics were determined, and a meta-analysis was performed.

resultsNine studies of diagnostic tests were included based on a cutoff value of 35. The following overall values were obtained: the sensitivity was 0.69 (95% confidence interval [CI] 0.61-0.75); specificity was 0.65 (95% CI 0.553-0.733); the diagnostic odds ratio (DOR) was 4.244 (95% CI 3.487-5.166); and the area under the curve was 0.734 (95% CI 0.674-0.805), with a heterogeneity of 0%.

conclusionsUrinary PCA3 has an acceptable diagnostic accuracy, aids in the study of patients with suspected PCa, and can be used as a guide for directing the performance of the first prostate biopsy and decreasing unnecessary biopsies.

Identifiers

PMID31793864
PMCPMC7197956
OpenAlexW2989769682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.