Evidence map›Paper›PMID 31793707›Full record

ArticleJournal of cellular and molecular medicine2020

Increased proliferation of hepatic periportal ductal progenitor cells contributes to persistent hypermetabolism after trauma.

Li Diao, Yusef Yousuf, Saeid Amini-Nik, Marc G Jeschke

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Li DiaoSunnybrook Research Institute, Toronto, ON, Canada.
Yusef YousufSunnybrook Research Institute, Toronto, ON, Canada.
Saeid Amini-NikSunnybrook Research Institute, Toronto, ON, Canada.ORCID 0000-0002-9185-9456
Marc G JeschkeSunnybrook Research Institute, Toronto, ON, Canada.ORCID 0000-0003-0870-1664
Sunnybrook Hospital · CASunnybrook Health Science Centre · CAUniversity of Toronto · CA

Funding

Hepatic ER stress contributes to morbidity and mortality after burn injury.R01GM087285 · NIGMS · SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR · PI BOEHNING, DARREN F, JESCHKE, MARC GERHARD · 2010 to 2018
$1.9M
NIGMS NIH HHS R01 GM087285
6 · The paper itself

Abstract

Prolonged and persistent hypermetabolism and excessive inflammatory response after severe trauma is detrimental and associated with poor outcome. The predisposing pathology or signals mediating this complex response are essentially unknown. As the liver is the central organ mediating the systemic metabolic responses and considering that adult hepatic stem cells are on top of the hierarchy of cell differentiation and may pass epigenetic information to their progeny, we asked whether liver progenitor cells are activated, signal hypermetabolism upon post-traumatic cellular stress responses, and pass this to differentiated progeny. We generated Sox9CreER

Indexed as

AnimalsBurnsCell ProliferationDown-RegulationHepatomegalyHot TemperatureInflammationLiverLiver X ReceptorsMice, TransgenicPortal SystemReceptors, Retinoic AcidSignal TransductionStem CellsStress, PhysiologicalTranscriptomeLiver X ReceptorsReceptors, Retinoic Acidburnshepatocytesinflammationlineage-traceliver regenerationliver X receptormetabolismperiportal ductal progenitor cellstress response

Identifiers

PMID31793707
PMCPMC6991656
OpenAlexW2991854520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.