ArticleHippocampus2020
Hippocampal state transitions at the boundaries between trial epochs.
Article in Hippocampus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effective connectivity between the medial temporal lobes and early visual cortex modulated by unrestricted viewing predicts memory retrieval and gaze reinstatement.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The retrosplenial cortical role in delayed spatial alternation.Neurobiology of learning and memory · 2024Article
- The Retrosplenial Cortical Role in Delayed Spatial Alternation.bioRxiv : the preprint server for biology · 2024Article
- Hippocampal conjunctive and complementary CA1 populations relate sensory events to movement.iScience · 2023Article
- The neural bases for timing of durations.Nature reviews. Neuroscience · 2022Review
- Article
- The limbic memory circuit and the neural basis of contextual memory.Neurobiology of learning and memory · 2022Article
- Grounding the Attentional Boost Effect in Events and the Efficient Brain.Frontiers in psychology · 2022Review
- Structuring Knowledge with Cognitive Maps and Cognitive Graphs.Trends in cognitive sciences · 2021Review
- Review
- Hippocampal neurons represent events as transferable units of experience.Nature neuroscience · 2020Article
- Rapid Memory Reactivation at Movie Event Boundaries Promotes Episodic Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- In a Temporally Segmented Experience Hippocampal Neurons Represent Temporally Drifting Context But Not Discrete Segments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Event boundaries do not cause the immediate extinction deficit after Pavlovian fear conditioning in rats.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The hippocampus encodes distinct contexts with unique patterns of activity. Representational shifts with changes in context, referred to as remapping, have been extensively studied. However, less is known about transitions between representations. In this study, we leverage a large dataset of neuronal recordings taken while rats performed an olfactory memory task with a predictable temporal structure involving trials and intertrial intervals (ITIs), separated by salient boundaries at the trial start and trial end. We found that trial epochs were associated with stable hippocampal representations despite moment-to-moment variability in stimuli and behavior. Representations of trial and ITI epochs were far more distinct than spatial factors would predict and the transitions between the two were abrupt. The boundary was associated with a large spike in multiunit activity, with many individual cells specifically active at the start or end of each trial. Both epochs and boundaries were encoded by hippocampal populations, and these representations carried information on orthogonal axes readily identified using principal component analysis. We suggest that the hippocampus orthogonalizes representations of the trial and ITI epochs and the activity spike at trial boundaries might serve to drive hippocampal activity from one stable state to the other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.