Evidence map›Paper›PMID 31793232›Full record

ArticleCongenital heart disease2019

Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury.

Dana Y Fuhrman, Lan Nguyen, Morgan Hindes, John A Kellum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Congenital heart disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dana Y FuhrmanDepartment of Critical Care Medicine, The Center for Critical Care Nephrology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.ORCID https://orcid.org/0000-0002-3672-7960
Lan NguyenDepartment of Pediatrics, Division of Pediatric Cardiology, The Center for Critical Care Nephrology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Morgan HindesDepartment of Pediatrics, Division of Pediatric Cardiology, The Center for Critical Care Nephrology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
John A KellumDepartment of Critical Care Medicine, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Children's Hospital of Pittsburgh · US

Funding

Renal Fitness in Young Adults with Congenital Heart DiseaseK23DK116973 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FUHRMAN, DANA YOUNG · 2019 to 2023
$1.2M
NIDDK NIH HHS K23 DK116973NIDDK NIH HHS K23DK116973NIH HHS
6 · The paper itself

Abstract

backgroundThere are significant implications for kidney disease in young adults with congenital heart disease. Prior investigations have not focused on the use of urinary tubular biomarkers for the early identification of kidney disease in this growing patient group.

objectiveDetermine if young adults with congenital heart disease have differences in the baseline concentration of urinary tubular biomarkers when compared to healthy young adults. DESIGN/

methodsIn a pilot case control study, 30 patients from 18 to 35 years of age with congenital heart disease and a normal serum creatinine were recruited during a routine follow-up visit. In the same age group, 30 control subjects without history of heart or kidney disease were recruited. Urine samples were obtained to measure beta 2-microglobin, alpha 1-microglobin, N-acetyl-B-D-glucosaminidase, liver fatty acid binding protein, kidney injury molecule-1, insulin-like growth factor binding protein 7, and tissue inhibitor of metalloproteinases-2. Comparisons were done using Wilcoxon rank-sum or Fisher's exact test.

resultsNo study participants had proteinuria on urine dipstick. Median concentrations of kidney injury molecule-1 were higher (P = .01) and concentrations of insulin-like growth factor binding protein 7 (P = .001) and tissue inhibitor of metalloproteinases-2 (P = .009) were lower in the subjects with congenital heart disease when compared to the control subjects. There were no significant differences between the groups with respect to the other biomarkers.

conclusionOur data suggest that young adults with congenital heart disease may have subclinical kidney dysfunction. Lower levels of insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2 may indicate an impaired ability to respond to injury, while higher levels of kidney injury molecule-1 may reflect early tubular injury.

Indexed as

AdolescentAdultAsymptomatic DiseasesBiomarkersCase-Control StudiesFemaleHeart Defects, CongenitalHepatitis A Virus Cellular Receptor 1HumansInsulin-Like Growth Factor Binding ProteinsKidney DiseasesKidney TubulesMalePilot ProjectsPredictive Value of TestsPrognosisBiomarkersHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1insulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2congenital heart diseasekidney injurytubular injury markersurinary biomarkers

Identifiers

PMID31793232
PMCPMC6952564
OpenAlexW2993837956

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.