ArticleJournal of applied clinical medical physics2019
A study of nonuniform CTV to PTV margin expansion incorporating both rotational and translational uncertainties.
Article in Journal of applied clinical medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Setup Error Differences and Margin Expansion Among Rectal Cancer Segments: Consistency Evaluation Between EPID and iSCOUT.Cancer reports (Hoboken, N.J.) · 2026Article
- Assessment of the mechanical performance of a novel CT-linac treatment couch.Frontiers in oncology · 2026Article
- Spiral volumetric modulated arc therapy for whole-brain radiotherapy with simultaneous integrated boost to multiple brain metastases.Radiation oncology (London, England) · 2025Article
- Dosimetric advantages of dual-layer MLC in hypofractionated stereotactic radiotherapy for multiple brain metastases: a comparative study with single-layer MLC.Frontiers in oncology · 2025Article
- Analysis of the impact of rotation error on PTV margins in multiple brain metastases fractionated stereotactic radiotherapy based on single-isocenter multi-target technique.Frontiers in oncology · 2025Article
- Effect of different optimization parameters in single isocenter multiple brain metastases radiosurgery.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- Treatment planning with high-resolution 3D dose maps in preclinical and translational synchrotron microbeam radiation therapy.Physics and imaging in radiation oncology · 2024Article
- Optimization of isocenter position for multiple targets with nonuniform-margin expansion.Journal of applied clinical medical physics · 2023Article
- Evaluation of Plan Robustness Using Hybrid Intensity-Modulated Radiotherapy (IMRT) and Volumetric Arc Modulation Radiotherapy (VMAT) for Left-Sided Breast Cancer.Bioengineering (Basel, Switzerland) · 2022Article
- Setup uncertainties and appropriate setup margins in the head-tilted supine position of whole-brain radiotherapy (WBRT).PloS one · 2022Article
- Predicting the effect of indirect cell kill in the treatment of multiple brain metastases via single-isocenter/multitarget volumetric modulated arc therapy stereotactic radiosurgery.Journal of applied clinical medical physics · 2021Article
- Dosimetric study between a single isocenter dynamic conformal arc therapy technique and Gamma Knife radiosurgery for multiple brain metastases treatment: impact of target volume geometrical characteristics.Radiation oncology (London, England) · 2021Article
- Longitudinal Grouping of Target Volumes for Volumetric-Modulated Arc Therapy of Multiple Brain Metastases.Frontiers in oncology · 2021Article
- Rotational Set Up Uncertainly in Non-6D Couch and its Effects in Clinical Target Volume- Planning Target Volume Margin Calculation for Different Sites.Journal of medical physicsArticle
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5 authors.
Funding
Abstract
purposeIn this work, we implemented a method to obtain a nonuniform clinical target volume (CTV) to planning target volume (PTV) margin caused by both rotational and translational uncertainties and evaluated it in the treatment planning system (TPS). MATERIALS AND
methodBased on a previously published statistical model, the relationship between a target margin and the distance d (from isocenter to target point), setup uncertainties, and significance level was established. For a single CTV, it can be thought as a combination of many small volume elements or target points. The margin of each point could be obtained using the suggested statistical model. The whole nonuniform CTV-PTV margin was determined by the union of all possible margins of the CTV boundary points. This method was implemented in the Pinnacle
resultsThe combined CTV-PTV margin as a function of d for various initial translational margin and rotational uncertainties was calculated. The combined margin increases as d, rotational uncertainties and translational margin increase. For the same rotational uncertainty, a smaller initial translational margin requires a larger rotational margin to compensate for the rotational error. Compared with the uniform margin algorithm, the advantage of this method is that it could minimize the PTVs volume for given CTVs to obtain same significance level. Using vertebral metastases targets and multiple brain metastases targets, a series of volume difference was obtained for various translational margins and rotational uncertainties. The volume difference of PTV could be more than 17% when translational margin is 2 mm and rotational uncertainty is 1.4°.
conclusionNonuniform margin algorithm could avoid excessive compensation for the CTV boundary points near isocenter. This method could be used for clinical margin determination and might be useful for the protection of risk organs.
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