ArticlePsychiatry and clinical neurosciences2020
Brain morphological and functional features in cognitive subgroups of schizophrenia.
Article in Psychiatry and clinical neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Brain Morphological Characteristics of Cognitive Subgroups of Schizophrenia-Spectrum Disorders and Bipolar Disorder: A Systematic Review with Narrative Synthesis.Neuropsychology review · 2023Pooled it
- Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation.Frontiers in psychiatry · 2022Pooled it
- Cerebellar gray matter volume changes in patients with schizophrenia: A voxel-based meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- The role of the globus pallidus subregions in the schizophrenia spectrum continuum.Molecular psychiatry · 2026Article
- Cognitive profiles of patients with enlarged lateral ventricles and cognitive impairment among patients with schizophrenia.Schizophrenia research. Cognition · 2026Article
- A multilayered model of work outcome in patients with schizophrenia: Examination of the relationships among positive symptoms, cognition, and daily living skills.Schizophrenia research. Cognition · 2026Article
- Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Driving Performance in Schizophrenia: The Role of Neurocognitive Correlates-A Systematic Review.Brain sciences · 2025Review
- Clinical Characteristics of Patients With Enlarged Ventricles and Cognitive Impairment (EVCI): Case Series.Neuropsychopharmacology reports · 2025Article
- Characterizing multivariate regional hubs for schizophrenia classification, sex differences, and brain age estimation using explainable AI.medRxiv : the preprint server for health sciences · 2025Article
- Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data-Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders.Neuropsychopharmacology reports · 2025Article
- Deterioration in cognitive control related mPFC function underlying development of treatment resistance in early psychosis.Scientific reports · 2024Article
- Association between homotopic connectivity and clinical symptoms in first-episode schizophrenia.Heliyon · 2024Article
- Distinct multimodal biological and functional profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2024Article
- Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function.Neuropsychopharmacology reports · 2024Article
- Influence of TMX2-CTNND1 polymorphism on cortical thickness in schizophrenia patients and unaffected siblings: an exploratory study based on target region sequencing.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2024Article
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.Molecular psychiatry · 2023Article
- Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals.Molecular psychiatry · 2023Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
aimPrevious studies have reported different brain morphologies in different cognitive subgroups of patients with schizophrenia. We aimed to examine the brain structures and functional connectivity in these cognitive subgroups of schizophrenia.
methodsWe compared brain structures among healthy controls and cognitively deteriorated and preserved subgroups of patients with schizophrenia according to the decline in IQ. Connectivity analyses between subcortical regions and other brain areas were performed using resting-state functional magnetic resonance imaging among the groups.
resultsWhole brain and total cortical gray matter, right fusiform gyrus, left pars orbitalis gyrus, right pars triangularis, left superior temporal gyrus and left insula volumes, and bilateral cortical thickness were decreased in the deteriorated group compared to the control and preserved groups. Both schizophrenia subgroups had increased left lateral ventricle, right putamen and left pallidum, and decreased bilateral hippocampus, left precentral gyrus, right rostral middle frontal gyrus, and bilateral superior frontal gyrus volumes compared with controls. Hyperconnectivity between the thalamus and a broad range of brain regions was observed in the deteriorated group compared to connectivity in the control group, and this hyperconnectivity was less evident in the preserved group. We also found hyperconnectivity between the accumbens and the superior and middle frontal gyri in the preserved group compared with connectivity in the deteriorated group.
conclusionThese findings provide evidence of prominent structural and functional brain abnormalities in deteriorated patients with schizophrenia, suggesting that cognitive subgroups in schizophrenia might be useful biotypes to elucidate brain pathophysiology for new diagnostic and treatment strategies.
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